MRI与MRS在肥胖症研究中的应用进展

doi:10.11938/cjmr20160116

摘要/Abstract

摘要：

肥胖症已经成为严重威胁人类健康的主要慢性疾病之一,磁共振成像(MRI)和磁共振波谱(MRS)技术的结合运用,对于评价脂肪组织分布和蓄积程度具有极大的优势.该文总结了近年来MRI与MRS技术在肥胖症研究中的应用进展,并讨论了MRI与MRS技术在肥胖症临床应用及科学研究中的价值.

关键词: 磁共振成像(MRI), 磁共振波谱(MRS), 肥胖症, 小鼠模型

Abstract:

Obesity has become a serious threat to human health. Magnetic resonance imaging (MRI) and in vivo magnetic resonance spectroscopy (MRS) provide powerful tools for evaluating the distribution and accumulation of adipose tissues in the body. Here, we reviewed the recent progresses in the applications of MRI and MRS technologies in basic and clinical researches on obesity.

Key words: magnetic resonance imaging (MRI), magnetic resonance spectroscopy (MRS), obesity, mouse model

中图分类号:

O482.53

王璐璐, 朱勇, 钟凯. MRI与MRS在肥胖症研究中的应用进展[J]. 波谱学杂志, 2016, 33(1): 168-178.

WANG Lu-lu, ZHU Yong, ZHONG Kai. Progresses in MRI and MRS Studies on Obesity[J]. Chinese Journal of Magnetic Resonance, 2016, 33(1): 168-178.

参考文献

[1] Westman E, Wahlund LO, Foy C, et al. Combining MRI and MRS to distinguish between Alzheimer's disease and healthycontrols[J]. J Alzheimers Dis, 2010, 22(1): 171－181.

[2] Langkammer C, Ropele S, Pirpamer L, et al. MRI for iron mapping in Alzheimer's disease[J]. Neurodegener Dis, 2014, 13(2, 3): 189－191.

[3] Seppi K. MRI for the differential diagnosis of neurodegenerative parkinsonism in clinical practice[J]. Parkinsonism Relat D, 2007, 13(S3): 400－405.

[4] Choi C B, Kim S Y, Lee S H, et al. Assessment of metabolic changes in the striatum of a rat model of parkinsonism: An in vivo ¹H MRS study[J]. Magn Reson Imaging, 2011, 29(1): 32－39.

[5] Seppi K, Schocke M F. An update on conventional and advanced magnetic resonance imaging techniques in the differential diagnosis of neurodegenerative parkinsonism[J]. Curr Opin Neurol, 2005, 18(4): 370－375.

[6] deBucourt M, Streitparth F, Wonneberger U, et al. Obese patients in an open MRI at 1.0 Tesla: Imagequality, diagnostic impact and feasibility[J]. Eur Radiol, 2011, 21(5): 1 004－1 015.

[7] Brennan D D, Whelan P F, Robinson K, et al. Rapid automated measurementof body fat distribution fromwhole-body MRI[J]. AJR Am J Roentqenol, 2005, 185(2): 418－423.

[8] Fan Ming-xia(范明霞), Tian Jian-ming(田建明), Lu Jian-ping(陆建平), et al. Preliminary evaluation of fatty liver in rats by in vivo ¹H-NMR spectroscopy(活体¹H磁共振波谱分析在大鼠脂肪肝中应用价值的初步研究)[J]. Chin J Med Imaging Technol(中国医学影像技术), 2004, 20(10): 1 503－1 505.

[9] Liu Zhi-jun(刘志军). The development and enlightenment of nuclear magnetic resonance(核磁共振研究的历史)[J]. Journal of Guangxi University for Nationalities(广西民族大学学报), 2011, 17(2): 25－28.

[10] Zhang Yun(张云). The history of nuclear magnetic resonance technology and its application(核磁共振技术的历史及应用)[J]. Science & Technology Information(科技信息), 2010, 15: 116－118.

[11] Lauterbur P C. Image format ion by induced local interactions: Examples employing nuclear magnetic resonance[J]. Nature, 1973, 242: 190－191.

[12] Xian Ru-hong(羡汝珙), Li Yu-huan(李宇寰), Cui Li-ke(崔力科). High field MR imaging and spectroscopy(高场磁共振成像和波谱学)[J]. CT Theory and Applications(CT理论与应用研究), 1994, 3(4): 24－27.

[13] Ni Ping(倪萍), Zhao Ming(赵明), Chen Zi-qian(陈自谦). Developmet and recent progress of MRI magnetic technology (MRI磁体技术的发展历程及展望)[J]. China Medical Equipment(中国医疗设备), 2013, 28(10): 6－10.

[14] Marks S J, Moore N R, Ryley N G, et al. Measurement of liver fat by MRI and its reduction by dexfenfluramine in NIDDM[J]. Int J Obes Relat Metab Disord, 1997, 21(4): 274－279.

[15] Cassidy F H, Yokoo T, Aganovic L, et al. Fatty liver disease: MR imaging techniques for the detection and quantificationof liver steatosis[J]. Radiographics, 2009, 29(1): 231－260.

[16] Ducluzeau P H, Boursier J, Bertrais S, et al. MRI measurement of liver fat content predicts the metabolic syndrome[J]. Diabetes Metab, 2013, 39(4): 314－321.

[17] Kim S, Naik M, Sigmund E, et al. Diffusion-weighted MR imaging of the kidneys and the urinary tract[J]. Magn ResonImaging C, 2008, 16(4): 585－596.

[18] Jin Er-hu(靳二虎), Zhang Jie(张洁), Ma Da-qing(马大庆). MR imaging of anatomical variations and fatty deposit of the pancreas(胰腺解剖变异和脂肪沉积的MRI表现)[J]. Chinese J Magn Reson Imaging(磁共振成像), 2012, 3(3): 213－221.

[19] Zhao Hua-li(赵华丽), Chen Ke-min(陈克敏). Application of MRI breast imaging reporting and data system in breast lesions(MRI乳腺影像报告及数据系统在乳腺疾病诊断中的应用研究)[J]. Journal of Diagnostics Concepts & Practice (诊断学理论与实践), 2011, 10(5): 454－458.

[20] Xiao De-yong(肖德勇). MR Imaging Characteristics and Clinical Pathologic Correlation about Intrapituitary Cystic Degeneration and Fluid-fluid Level Formation(垂体腺瘤囊变及液平面形成的MRI特征与临床病理研究)[D]. Fuzhou(福州): Fujian Medical University(福建医科大学), 2012.

[21] Wu Dao-qing(吴道清), Chen Zi-qian(陈自谦). Evaluation of MR imaging with dynamic contrast-enhancement and diffusion-weighted imaging in diagnosis of prostatic diseases(DCE-MRI与DWI对良恶性前列腺疾病诊断的价值)[J]. Journal of Clinical Radiology(临床放射学杂志), 2010, 29(2): 211－215.

[22] Ni Hong-bin(倪红斌), Liang Wei-bang(梁维邦), Ji Jing(季晶), et al. MRI in patients with cranial nerve disease and find out the neurovascular relationships(MRI在了解颅神经疾病患者血管神经关系上的作用)[J]. Jiangsu Medical Journal(江苏医药), 2005, 31(9): 716.

[23] Andreasen N C. Linking mind and brain in the study of mental illnesses: A project for a scientific psychopathology[J]. Science, 1997, 275(5 306): 1 586－1 593.

[24] Hu H H, Nayak K S, Goran M I. Assessment of abdominal adipose tissue and organ fat content by magnetic resonanceimaging[J]. Obes Rev, 2011, 12(5): e504－515.

[25] Li Jing-jing(李晶晶), Yang Cheng-gang(杨成刚), Zhang Jun(张郡). The application of conventional MR and MR arthrography in the rotator cuff tear(常规MRI及MRI肩关节造影在肩袖撕裂中的应用)[J]. Chinese Imaging Journal of Interated Traditional and Western Medicine(中国中西医结合影像学杂志), 2013, 11(04): 357－358.

[26] Li Zhen-feng(李振峰). Study of 3 T Magnetic Resonance Spectroscory in Patients with Bone and Soft Tissue Tumors(3 T 磁共振波谱在骨与软组织肿瘤中的应用)[D]. Jinan(济南): Shandong University(山东大学), 2007.

[27] Du Xiang-ke(杜湘珂), Feng Yi-lian(冯义廉). Medical MRS is a method of the function of human body metabolic disease examination(医学磁共振波谱是人体功能代谢病生理检查的一种方法)[J]. Chinese J Radiol(中华放射学杂志), 2000, 34(11): 725－726.

[28] He Juan(贺涓). The development status of MRI and MRS evaluation of multiple sclerosis(MRI和MRS评价多发硬化的发展现状)[J]. Foreign Medical Sciences Clinical Radiological Fascicle(国外医学临床放射学分册), 2006, 6: 331－334.

[29] Yang Zhi-hong(杨志宏), Cao Jie(曹杰), Zhang Jia(张佳), et al. Clinical application value of 3.0 T ¹H-MRS in diagnosis of non-alcoholic fatty liver(3.0 T 磁共振¹H-MRS诊断非酒精性脂肪肝的临床应用价值)[J]. Chinese J CT and MRI(中国CT和MRI杂志), 2014, 12(8): 41－43.

[30] Zhao Shuang(赵爽), Li Cai-ying(李彩英), Gao Feng-xiao(高凤宵), et al. The preliminary study of metabolite quantitative of normal livers and hepatic steatosis using 3.0 T ¹H-MRS (3.0 T ¹H-MRS 在正常肝脏与脂肪肝的对照研究)[J]. Journal of Clinical Radiology(临床放射学杂志), 2013, 32(2): 202－206.

[31] Hong Bi-kai(洪璧楷), Dai Hai-yang(代海洋), Xiao Ye-yu(肖叶玉), et al. 9.4 T MR spectroscopy detection of mesenchymal stem cells into osteoblasts metabolism characteristics(9.4 T MR 波谱检测间充质干细胞成骨分化代谢特征的研究)[J]. Chin J Magn Reson Imaging(磁共振成像), 2013, 4(6): 437－440.

[32] Li Feng(李锋), Liu Ke(刘克). The MRI and ¹H-MRS study of primary central nervous system lymphomas(PCNSL)(原发性中枢神经系统淋巴瘤的MRI与¹H-MRS 研究)[J]. J Med Imaging(医学影像学杂志), 2010, 20(9): 1 274－1 277.

[33] Cao Lian-ping(曹连平). A Proton Magnetic Resonance Spectroscopy Study on the Clinical Heterogeneity of Idiopathic Parkinson's Disease(原发性帕金森病临床异质性的¹H-MRS研究)[D]. Fuzhou(福州): Fujian Medical University(福建医科大学), 2013.

[34] Wang Jia(王佳), Fan Guo-guang(范国光). Study of ¹H-MR spectroscopy in the peritumoral area of gliomas(脑胶质瘤周围区的¹H-MRS研究)[J]. Int J Med Radiol(国际医学放射学杂志), 2010, 33(1): 58－62.

[35] Shen Bian-hong(申变红), Li Guo-hai(李国海), Zhang Li-rong(张礼荣), et al. A study on terior cingulate glutamate levels in major depressive patients using proton magnetic resonance spectroscopy(抑郁症患者前扣带回谷氨酸多体素¹H-MRS研究)[J]. J Clin Psychiatry(临床精神医学杂志), 2008, 18(5): 324－326.

[36] Yan You-xia(颜有霞), Liang Chang-hong(梁长虹), Huang Biao(黄飚), et al. MRI and magenetic resonance spectroscopy study of hippocampal sclerosis(海马硬化的MRI及¹H-MRS研究)[J]. Radiol Practice(放射学实践), 2008, 23(1): 17－19.

[37] Yan Min(闫敏), Ou Xiao-qi(欧孝琪). The harm of obesity and its research progress(肥胖症的危害及其研究进展)[J]. Tibetan Journal of Medicine(西藏医药杂志), 2004, 25(3): 27－29.

[38] Galli M M, Protzman N M, Mandelker E M, et al. Comparing tendinous and ligamentous ankle pathology in atraumatic overweight and nonoverweight patients: A comprehensive MRI review[J]. Foot Ankle Spec, 2014, 7(6): 449－456.

[39] Ma Jun(马君), Wang Jun-qin(王菊勤), Han Ying(韩英), et al. New progress in obesity research(肥胖症研究新进展)[J]. Foreign Medical Sciences(国外医学: 护理学分册), 2000, 19(7): 310－311.

[40] Chen Jian-shuang(陈建双), Zhao Lei(赵蕾), Yuan Ya-fei(袁亚非). The progress in obesity research(肥胖症研究进展)[J]. Journal of Chengde Medical College(承德医学院学报), 2007, 24(2): 191－193.

[41] Fabbrini E, Magkos F, Mohammed B S, et al. Intra hepatic fat, not visceral fat, is linked with metabolic complications of obesity[J]. Proc Natl Acad Sci USA, 2009, 106(36): 15 430－15 435.

[42] Rasouli N, Kern P A. Adipocytokines and the metabolic complications of obesity [J]. J Clin Endocrinol Metab, 2008, 93(11): 64－73.

[43] Teede H J, Lombard C, Deeks A A. Obesity, metabolic complications and the menopause: An opportunity for prevention[J]. Climacteric, 2010, 13(3): 203－209.

[44] Artz N S, Haufe W M, Hooker C A, et al. Reproducibility of MR-based liver fat quantification across field strength: same-day comparison between 1.5 T and 3 T in obese subjects[J]. J Magn Reson Imaging, 2015, 42(3): 811－817.

[45] Alderete T L, Toledo-Corral C M, Desai P, et al. Liver fat has a stronger association with risk factors for type 2 diabetes in african-american compared with hispanic adolescents[J]. J Clin Endocrinol Metab, 2013, 98(9): 3 748－3 754.

[46] Zhu An-hui(祝安惠), Cui Bin(崔斌), Yao Dan(姚丹), et al. The correlation of abdominal fat distribution and diabetes mellitus(腹部脂肪分布与糖尿病的相关性研究)[J]. Journal of China Clinic Medical Imaging(中国临床医学影像杂志), 2012, 23(12): 849－852.

[47] Sun Wan-li(孙万里), Chen Liang(陈亮), Zhang Li-hua(张丽华), et al. Mesurement of abdominal adipose tissue by MRI(MRI 测量人腹部脂肪组织)[J]. Radiol Practice(放射学实践), 2007, 22(4): 405－406.

[48] Peng Xin-gui(彭新桂), Ju Sheng-hong(居胜红), Teng Gao-jun(滕皋军). Multiple Genes Rat Adipose Tissue in vivo MRI Chemical Shift Imaging and Spectral Analysis(多种基因鼠脂肪组织的活体MRI化学位移成像及波谱分析)[C]. Zhejiang(浙江): The Chinese Medical Association 16th National Radiology Academic Conference Proceedings(中华医学会第16次全国放射学学术大会论文汇编). 2009.

[49] Qian Jie(钱杰), Zhang Yu-bin(张玉彬). Brown adipose tissue and new targets for obesity treatment(棕色脂肪组织与肥胖症药物治疗的新靶点)[J]. Progress in Pharmaceutical Sciences(药学进展), 2012, 36(11): 487－493.

[50] Liu Gang(刘刚), Huang Yu-shan(黄玉山). The probe into obesity and its endangerment(肥胖及相关问题的认识)[J]. Journal of Shandong Physical Education Institute(山东体育学报), 2001, 51(3): 28－30.

[51] Hu H H, Kim H W, Nayak K S, et al. Comparison of fat-water MRI and single-voxel MRS in the assessment of hepatic and pancreatic fat fractions in humans[J]. Obesity (Silver Spring), 2010, 18(4): 841－847.

[52] Hu Xiao-dong(胡晓东), Li Hong-yan(李鸿炎). Establishment of a mouse model of diet-induced olbesity(饮食诱导小鼠肥胖疾病模型的建立)[J]. Journal of Nanchang University (Medical Science) [南昌大学学报(医学版)], 2012, 52(8): 6－9.

[53] Boggiano M M, Artiga A I, Pritchett C E, et al. High intake of palatable food predicts binge-eating independent of susceptibility to obesity: An animal model of lean vs obese binge-eating and obesity with and without binge-eating[J]. Int J Obes (Lond), 2007, 31(9): 1 357－1 367.

[54] Corwin R L, Wojnicki F H, Fisher J O, et al. Limited access to a dietary fat option affects ingestive behavior but not body composition in male rats[J]. Physiol Behav, 1998, 65(3): 545－553.

[55] Podrini C, Cambridge E L, Lelliott C J, et al. High-fat feeding rapidly induces obesity and lipid derangements in C57BL/6N mice[J]. Mamm Genome, 2013, 24(5, 6): 240－251.

[56] Tian Fang(田方), Jin Hong-xing(金红星), Cheng Wen-yu(成文玉). Construction of mouse nutritional obesity model(小鼠营养性肥胖模型的建立)[J]. Journal of Anhui Agricultural Sciences(安徽农业科学), 2008, 36(36): 15 963－15 964.

[57] Tian Hui(田辉), Wang Yu-ting(王玉婷), Tao Li(陶莉), et al. A new model of obese mice(一种新型小鼠肥胖模型的建立)[J]. Chinese Pharmacological Bulletin(中国药理学通报), 2013, 29(7): 1 016－1 018.

[58] Qian Bo-chu(钱伯初), Shi Hong(史红), Lv Yan-ping(吕燕萍). Progress in studies of preparation of obesity animal models(肥胖动物模型的研究进展)[J]. Chinese Journal of New Drugs(中国新药杂志), 2007, 16(15): 1 159－1 162.

[59] Liu Fang(刘芳). Comparison and Mechanism of Obesity Models Established in Different Strains of Mice & Antiobesity Effects and Mechanism of LRTG(不同品系小鼠肥胖模型比较、肥胖机制研究&LRTG减肥作用及作用机理探讨)[D]. Beijing(北京): Peking Union Medical College Hospital(北京协和医学院), 2013.

[60] Liu Jin-feng(刘金凤), Dong Huan-sheng(董焕生), Pan Qing-jie(潘庆杰), et al. Induction of obesity and insulin resistance in mice using a modified diet(食源性肥胖小鼠胰岛素抵抗模型的建立)[J]. Editorial Dept of Journal of QAU(青岛农业大学学报: 自然科学版), 2014, 31(2): 91－94.

[61] Wang Shu-ran(王舒然), Ma Wei-wei(麻微微), Zhao Dan(赵丹), et al. Establishment of obesity prone and obesity resistant rats induced by high-fat diet(高脂饮食诱导肥胖与肥胖抵抗动物模型建立)[J]. Chinese Journal Public Health(中国公共卫生), 2007, 23(07): 774－775.

[62] Machann J, Horstmann A, Born M, et al. Diagnostic imaging in obesity[J]. Best Pract Res Cl En, 2013, 27(2): 261－277.

[63] Ducluzeau PH, Boursier J, Bertrais S, et al. MRI measurement of liver fat content predicts the metabolic syndrome[J]. Diabetes Metab, 2013, 39(4): 314－321.

[64] Lunati E, Marzola P, Nicolato E, et al. In vivo quantitative hydrolipidic map of perirenal adipose tissue by chemical shiftimaging at 4.7 tesla[J]. J Lipid Res, 1999, 40(8): 1 395－1 400.

[65] Liu Yu-bao(刘于宝), Liang Chang-hong(梁长虹). The progress of qualitative and quantitative research in fatty liver withMRI(MRI 定性定量研究脂肪肝的进展)[J]. Journal of Clinical Radiology(临床放射学杂志), 2006, 25(10): 975－978.

[66] Li Shao-rui(李少蕊), Weng De-he(翁得河), Chen Hui-cheng(陈会城). A water-fat separation magnetic resonance imagemethod based on inversion recovery(基于反转恢复技术的水脂分离磁共振成像方法)[J]. Chinese J Magn Reson(波谱学杂志), 2012, 29(4): 547－553.

[67] Peng Xin-gui(彭新桂), Ju Sheng-hong(居胜红), Teng Gao-jun(滕皋军). (MR活体脂肪成像和波谱分析)[J]. Chin J Radiol(中华放射学杂志), 2009, 43(8): 894－897.

[68] Bao J, Cui X, Cai S, et al. Brown adipose tissue mapping in rats with combined intermolecular double-quantum coherenceand Dixon water-fat MRI[J]. NMR Biomed, 2013, 26(12): 1 663－1 671.

[69] Wang Xiao-hong(王小红), Zhang Qin-ta(张钦塔), Lin Yan-qin(林雁勤), et al. Two-dimensional localized magnetic resonance spectroscopy and its in vivo application(二维核磁共振定域谱及其在活体中的应用)[J]. Chinese J Magn Reson(波谱学杂志), 2011, 28(3): 419－436.

[70] Wattjes M P, Kley R A, Fischer D. Neuromuscular imaging in inherited muscle diseases[J]. Eur Radiol, 2010, 20(10): 2 447－2 460.

[71] Lee Y, Lingvay I, Szczepaniak L S, et al. Pancreatic steatosis: Harbinger of type 2 diabetes in obese rodents[J]. Int J Obes(Lond), 2010, 34(2): 396－400.

[72] Reeder S B, Cruite I, Hamilton G, et al. Quantitative assessment of liver fat with magnetic resonance imaging andspectroscopy[J]. J Magn Reson Imaging, 2011, 34(4): 729－749.

[73] Tian Bing(田冰), Huang Wen-cai(黄文才), Lu Jian-ping(陆建平). Application of proton magnetic resonance spectroscopy in somatic organs(体部器官¹H-MRS的应用)[J]. Chin J Med Imaging Technol(中国医学影像技术), 2011, 27(5): 1 082－1 085.

[74] Peng Xin-gui(彭新桂), Bai Ying-ying(柏盈盈), Ju Sheng-hong(居胜红). In vivo detection of fat quantitative and studyusing ¹H-MRS in ob/ob and WT mice (ob/ob与野生型小鼠脂肪组织的磁共振波谱研究)[J]. J Southeast Univ(东南大学学报), 2014, 33(3): 260－266.

[75] Lê KA, Faeh D, Stettler R, et al. A 4-wk high-fructose diet alters lipid metabolism without affecting insulin sensitivity orectopic lipids in healthy humans[J]. Am J Clin Nutr, 2006, 84(6): 1 374－1 379.

[76] Lee S J, Boesch C, Kuk J L, et al. Effects of an overnight intravenous lipid infusion on intramyocellular lipid content andinsulin sensitivity in African American versus Caucasian adolescents[J]. Metabolism, 2013, 62(3): 417－423.