波谱学杂志 ›› 2015, Vol. 32 ›› Issue (2): 354-362.doi: 10.11938/cjmr20150217

• 研究论文 • 上一篇    下一篇

先进固体核磁共振揭示苯硼酸-壳聚糖纳米粒子非均匀结构和相容性

王粉粉 1,陈铁红1,孙平川1,2,3*   

  1. 1. 功能高分子材料教育部重点实验室,南开大学,天津 300071;
    2. 药物化学生物学国家重点实验室,南开大学,天津 300071;
    3. 天津化学化工协同创新中心(天津),天津 300071
  • 收稿日期:2015-02-11 修回日期:2015-05-08 出版日期:2015-06-05 发布日期:2015-06-05
  • 作者简介:*通讯联系人:孙平川,电话:+86-22-23508171, E-mail: spclbh@nankai.edu.cn.
  • 基金资助:

    The National Natural Science Foundation of China (20825416, 21374051).

Heterogeneous Structure and Miscibility of Phenylboronic Acid-Rich Chitosan Nanoparticles as Revealed by Advanced Solid-State NMR

WANG Fen-fen1,CHEN Tie-hong1,SUN Ping-chuan1,2,3*   

  1. 1. Key Laboratory of Functional Polymer Materials of Ministry of Education and College of Chemistry, Nankai University, Tianjin 300071;
    2. State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin 300071;
    3. Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin 300071
  • Received:2015-02-11 Revised:2015-05-08 Online:2015-06-05 Published:2015-06-05
  • About author:WANG Fen-fen(1989-), female, born in Shandong, PhD., E-mail: wff@mail.nakai.edu.cn. *Corresponding author: SUN Ping-chuan, Tel: +86-22-23508171, E-mail: spclbh@nankai.edu.cn.
  • Supported by:

    The National Natural Science Foundation of China (20825416, 21374051).

摘要:

该文采用先进的固体核磁共振技术研究了壳聚糖-聚3-丙烯酰胺基苯硼酸纳米粒子非均匀结构和高分子间的相容性.13C CPMAS 实验表征了壳聚糖与苯硼酸结合后的构象变化,2D 13C-1H HETCOR 实验进一步证明了壳聚糖在界面处通过硼酸配位作用与苯硼酸链紧密相连.2D 1H-1H 自旋交换和扩散实验阐明了壳聚糖和聚苯硼酸的界面混合性,相分离尺度大约为15-20 nm.

关键词: 固体核磁共振, 非均匀结构, 相容性, 纳米粒子, 壳聚糖

Abstract:

By using advanced solid-state NMR techniques, the heterogeneous structure and inter-polymer miscibility of chitosan-poly (N-3-acrylamidophenyl-boronic acid) nanoparticles (CS-PAPBA NPs) were investigated. The 13C CPMAS experiments indicate the conformational change of chitosan when incorporated with phenyl boronic acid. Two-dimensional (2D) 13C-1H HETCOR experiments further demonstrate that a portion of chitosan is closely bound with
PAPBA in the interphase by means of boronic coordination interaction. 2D 1H-1H spin-exchange with spin-diffusion experiments demonstrate that the interfacial mixing of chitosan and PAPBA, and micro-phase separation is of the order of 15–20 nanometers.

Key words: solid-state NMR, heterogeneous structure, miscibility, nanoparticles, chitosan

中图分类号: