Two-Dimensional Localized Magnetic Resonance Spectroscopy and its In Vivo Application

Abstract

Abstract:

Localized magnetic resonance spectroscopy (MRS) is a non-invasive technique for acquiring in vivo biochemical and diagnostic information, acting as a powerful complement to MRI. It can provide important information for clinical diagnosis and disease prediction. However, 1D in vivo ¹H MRS has the problems of peak crowding, low spectral resolution and difficult peak identification. The twodimensional (2D) MRS has been introduced to address these problems to a large extent. In this review, we analyzed the advantages and disadvantages of several typical 2D MRS methods. Their in vivo applications in brain, muscle, breast and prostates were also discussed. Although 2D MRS has the limitation of long experimental time, it still holds some unique advantages and presents a promising prospect according to the latest research.

Key words: magnetic resonance spectroscopy, two-dimensional, in vivo, intermolecular multiple-quantum coherences, L-COSY

CLC Number:

O482.53

WANG Xiao-Hong, ZHANG Qin-Ta, LIN Yan-Qin, CHEN Zhong. Two-Dimensional Localized Magnetic Resonance Spectroscopy and its In Vivo Application[J]. Chinese Journal of Magnetic Resonance, 2011, 28(3): 419-436.

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