人脑 GABA-MRS 中回顾性运动校正方法研究

doi:10.11938/cjmr20150405

波谱学杂志 ›› 2015, Vol. 32 ›› Issue (4): 596-605.doi: 10.11938/cjmr20150405

人脑 GABA-MRS 中回顾性运动校正方法研究

张竹伟¹，陈录广²，裴孟超³，李建奇¹*

1. 华东师范大学物理系，上海市磁共振重点实验室，上海 200062；
2. 第二军医大学附属长海医院放射科，上海 200433；
3. 上海卡勒幅磁共振技术有限公司，上海 201614

收稿日期:2014-12-02 修回日期:2015-10-23 出版日期:2015-12-05 发布日期:2015-12-05
作者简介:张竹伟(1990-)，女，河南人，硕士研究生，无线电物理. *通讯联系人：李建奇，电话： 021-62223871，E-mail： jqli@phy.ecnu.edu.cn.
基金资助:
国家自然科学基金资助项目(81271533)

Retrospective Motion Correction in GABA-Editing Magnetic Resonance Spectroscopy Using the Residual Water Signals

ZHANG Zhu-wei¹，CHEN Lu-guang²，PEI Meng-chao³，LI Jian-qi^1*

1. Shanghai Key Laboratory of Magnetic Resonance, Department of Physics, East China Normal University, Shanghai 200062, China
2. Department of Radiology, Changhai Hospital of Shanghai, The Second Military Medical University, Shanghai 200433, China.
3. Shanghai Colorful Magnetic Resonance Co. Ltd., Shanghai 201614, China

Received:2014-12-02 Revised:2015-10-23 Online:2015-12-05 Published:2015-12-05
About author:*Corresponding author： LI Jian-qi, Tel: +86-21-62223871, E-mail: jqli@phy.ecnu.edu.cn.
Supported by:
国家自然科学基金资助项目(81271533)

摘要/Abstract

摘要：

运动会影响? -氨基丁酸(GABA)磁共振谱图质量，因此，数据采集后应对是否运动加以辨别并对运动的波谱数据作相应处理．该文报道了 GABA 磁共振活体波谱测量中回顾性运动校正后处理方法．该后处理方法通过残余水峰来判断被试扫描过程中的头部运动，重建时舍弃受运动影响的数据，从而改善最终得到的编辑谱的质量．同时该文将这种运动校正方法集成到 MEGA-PRESS 序列的重建模块中，使得扫描完成后能直接得到运动校正后的编辑谱，并可采用 LCModel 对编辑谱进行定量分析．研究结果表明，这种方法可以有效去除受运动影响的数据，使得最终得到的谱图质量明显改善，从而为医学诊断和研究提供便利．

关键词: γ-氨基丁酸(GABA), 磁共振波谱, 运动校正

Abstract:

Motions occurring during in vivo magnetic resonance spectroscopy acquisition limit the quality of the spectra and their diagnostic value. Subtraction-based spectral editing techniques, such as J-difference editing, are especially prone to motion artifacts, causing false peaks or incomplete elimination of the background. In this study, a retrospective motion correction post-processing method was introduced to analyze GABA-edited spectra acquired by a MEGA point-resolved spectroscopy (MEGA-PRESS) sequence. Head motion during each acquisition was detected and recorded by the residual water signal; the motion-corrupted data were identified and excluded prior to averaging. The gain in spectral quality by using the proposed method was analyzed using the LCModel program. The results showed that the proposed method is an effective way to discard acquisitions corrupted by motion, and to improve spectral quality.

Key words: magnetic resonance spectroscopy, motion correction, GABA

中图分类号:

O482.53

张竹伟1，陈录广2，裴孟超3，李建奇1*. 人脑 GABA-MRS 中回顾性运动校正方法研究
[J]. 波谱学杂志, 2015, 32(4): 596-605.

ZHANG Zhu-wei1， CHEN Lu-guang2， PEI Meng-chao3， LI Jian-qi1*. Retrospective Motion Correction in GABA-Editing Magnetic Resonance Spectroscopy Using the Residual Water Signals
[J]. Chinese Journal of Magnetic Resonance, 2015, 32(4): 596-605.

参考文献

[1] Agarwal N, Renshaw P F. Proton MR spectroscopy-detectable major neurotransmitters of the brain: biology and possible clinical applications[J]. AJNR Am J Neuroradiol, 2012, 33(4): 595－602.

[2] Graaf D Robin A. In vivo NMR Spectroscopy Principles and Techniques (2nd ed)[M]. Chichester: John Wiley & Sons, Ltd, 2007.

[3] Novotny E J, Jr, Fulbright R K, Pearl P L, et al. Magnetic resonance spectroscopy of neurotransmitters in human brain[J]. Ann Neurol, 2003, 54(S6): S25－31.

[4] McCormick D A. GABA as an inhibitory neurotransmitter in human cerebral cortex[J]. J Neurophysiol, 1989, 62(5): 1 018－1 027.

[5] Boy F, Evans C J, Edden R A, et al. Dorsolateral prefrontal gamma-aminobutyric acid in men predicts individual differences in rash impulsivity[J]. Biol Psychiatry, 2011, 70(9): 866－872.

[6] Petroff O A, Hyder F, Rothman D L, et al. Homocarnosine and seizure control in juvenile myoclonic epilepsy and complex partial seizures[J]. Neurology, 2001, 56(6): 709－715.

[7] Levy L M, Ziemann U, Chen R, et al. Rapid modulation of GABA in sensorimotor cortex induced by acute deafferentation[J]. Ann Neurol, 2002, 52(6): 755－761.

[8] Brambilla P, Perez J, Barale F, et al. GABAergic dysfunction in mood disorders[J]. Mol Psychiatry, 2003, 8(8): 721－737.

[9] Du F, Chu W J, Yang B, et al. In vivo GABA detection with improved selectivity and sensitivity by localized double quantum filter technique at 4.1 T [J]. Magn Reson Imaging, 2004, 22(1): 103－108.

[10] Epperson C N, Gueorguieva R, Czarkowski K A, et al. Preliminary evidence of reduced occipital GABA concentrations in puerperal women: A 1H-MRS study[J]. Psychopharmacology (Berl), 2006, 186(3): 425－433.

[11] Yoon J H, Maddock R J, Rokem A, et al. GABA concentration is reduced in visual cortex in schizophrenia and correlates with orientation-specific surround suppression[J]. J Neurosci, 2010, 30(10): 3 777－3 781.

[12] Puts N A, Edden R A. In vivo magnetic resonance spectroscopy of GABA: a methodological review[J]. Prog Nucl Magn Reson Spectrosc, 2012, 60: 29－41.

[13] Song Zhe(宋哲), Huang Pei-yu(黄沛钰), Qiu Li-hua(邱丽华), et al. Decreased occipital GABA concentrations in patients with first-episode major depressive disorder: A magnetic resonance spectroscopy study(重性抑郁症首发未用药患者的枕叶GABA 波谱研究)[J]. Journal of Biomedical Engineering(生物医学工程学杂志), 2012, 29(2): 233－236.

[14] Long Z, Medlock C, Dzemidzic M, et al. Decreased GABA levels in anterior cingulate cortex/medial prefrontal cortex in panic disorder[J]. Prog Neuro-Psychoph, 2013, 44: 131－135.

[15] Shaw A, Brealy J, Richardson H, et al. Marked reductions in visual evoked responses but not gamma-aminobutyric acid concentrations or gamma-band measures in remitted depression[J]. Biol Psychiatry, 2013, 73(7): 691－698.

[16] Bai X, Edden R A, Gao F, et al. Decreased gamma-aminobutyric acid levels in the parietal region of patients with Alzheimer's disease[J]. J Magn Reson Imaging, 2014, 41(5): 1 325－1 331.

[17] Coyle J T. The GABA-glutamate connection in schizophrenia: which is the proximate cause?[J]. Biochem Pharmacol, 2004, 68(8): 1 507－1 514.

[18] Petroff O A, Rothman D L, Behar K L, et al. Effects of valproate and other antiepileptic drugs on brain glutamate, glutamine, and GABA in patients with refractory complex partial seizures[J]. Seizure, 1999, 8(2): 120－127.

[19] Gao F, Edden R A, Li M, et al. Edited magnetic resonance spectroscopy detects an age-related decline in brain GABA levels[J]. Neuroimage, 2013, 78: 75－82.

[20] Pouwels P J, Brockmann K, Kruse B, et al. Regional age dependence of human brain metabolites from infancy to

adulthood as detected by quantitative localized proton MRS[J]. Pediatr Res, 1999, 46(4): 474－485.

[21] Zhou Kang-rong(周康荣), Chen Zu-wang(陈祖望). Body MRI(体部磁共振成像)[M]. Shanghai(上海): Shanghai Medical University Press(上海医科大学出版社), 2000.

[22] Mullins P G, McGonigle D J, O'Gorman R L, et al. Current practice in the use of MEGA-PRESS spectroscopy for the detection of GABA[J]. Neuroimage, 2014, 86: 43－52.

[23] Waddell K W, Avison M J, Joers J M, et al. A practical guide to robust detection of GABA in human brain by J-difference spectroscopy at 3T using a standard volume coil[J]. Magn Reson Imaging, 2007, 25(7): 1 032－1 038.

[24] Keltner J R, Wald L L, Frederick B D, et al. In vivo detection of GABA in human brain using a localized double-quantum filter technique[J]. Magn Reson Med, 1997, 37(3): 366－371.

[25] Rothman D L, Behar K L, Hetherington H P, et al. Homonuclear 1H double-resonance difference spectroscopy of the rat brain in vivo[J]. Proc Natl Acad Sci USA, 1984, 81(20): 6 330－6 334.

[26] de Graaf R A, Luo Y, Terpstra M, et al. Spectral editing with adiabatic pulses[J]. J Magn Reson B, 1995, 109(2): 184－193.

[27] Hetherington H P, Avison M J, Shulman R G. 1H homonuclear editing of rat brain using semiselective pulses[J]. Proc Natl Acad Sci USA, 1985, 82(10): 3 115－3 118.

[28] Bhattacharyya P K, Lowe M J, Phillips M D. Spectral quality control in motion-corrupted single-voxel J-difference editing scans: an interleaved navigator approach[J]. Magn Reson Med, 2007, 58(4): 808－812.

[29] Bogner W, Gagoski B, Hess A T, et al. 3D GABA imaging with real-time motion correction, shim update and reacquisition of adiabatic spiral MRSI[J]. Neuroimage, 2014, 103C: 290－302.

[30] Provencher S W. Automatic quantitation of localized in vivo 1H spectra with LCModel[J]. NMR Biomed, 2001, 14(4): 260 －264.

[31] Provencher S W. Estimation of metabolite concentrations from localized in vivo proton NMR spectra[J]. Magn Reson Med, 1993, 30(6): 672－679.

[32] Chen Lu-guang(陈录广), Li Jian-qi(李建奇), Wang Qian-feng(王前锋). Detection of GABA in human brain on clinical 3T MRI scanner(人脑 GABA 测量在临床 3T 磁共振成像系统上的实现)[J]. Chinese J Magn Reson(波谱学杂志), 2013, 30(3): 345－353.

[33] Star-Lack J M, Adalsteinsson E, Gold G E, et al. Motion correction and lipid suppression for 1H magnetic resonance spectroscopy[J]. Magn Reson Med, 2000, 43(3): 325－330.

[34] Dong Fang(董芳), Pei Meng-chao(裴孟超), Wang Qian-feng(王前锋), et al. Respiration-induced artifacts and navigator echo correction in gradient echo imaging on human brain(颅脑梯度回波成像: 呼吸伪影和导航回波矫正)[J]. Chinese J Magn Reson(波谱学杂志), 2014, 31(3): 321－330.

[35] Maas L C, Frederick B D, Renshaw P F. Decoupled automated rotational and translational registration for functional MRI time series data: the DART registration algorithm[J]. Magn Reson Med, 1997, 37(1): 131－139.

[36] Thesen S, Heid O, Mueller E, et al. Prospective acquisition correction for head motion with image-based tracking for real-time fMRI[J]. Magn Reson Med, 2000, 44(3): 457－465.

[37] Tremblay M, Tam F, Graham S J. Retrospective coregistration of functional magnetic resonance imaging data using external monitoring[J]. Magn Reson Med, 2005, 53: 141－149.

[38] Zaitsev M, Dold C, Sakas G, et al. Magnetic resonance imaging of freely moving objects: prospective real-time motion correction using an external optical motion tracking system[J]. Neuroimage, 2006, 31: 1 038－1 050.

人脑 GABA-MRS 中回顾性运动校正方法研究

Retrospective Motion Correction in GABA-Editing Magnetic Resonance Spectroscopy Using the Residual Water Signals

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