[1] Tang H R, Wang Y L. Metabonomics: A revolution in progress[J]. Prog Biochem Biophys, 2006, 33(5): 401-417.[2] Lindon J C, Holmes E, Nicholson J K. Recent development and applications of NMR-based metabonomics[J]. Chinese J Magn Reson(波谱学杂志), 2006, 23(1): 101-127.[3] Nicholson J K, Lindon J C, Holmes E. ´Metabonomics´: understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data[J]. Xenobiotica, 1999, 29(11): 1 181-1 189.[4] Constantinou M, Papakonstantinou E, Spraul M, et al. 1H MNR-based metabonomics for the diagnosis of inborn errors of metabolism in urine[J]. Anal Chim Acta, 2005, 542: 169-177.[5] Constantinou M, Papakonstantinou E, Benaki D, et al. Application of nuclear magnetic resonance spectroscopy combined with principal component analysis in detecting inborn errors of metabolism using blood Spots. A metabonomic approach[J]. Anal Chim Acta, 2004, 511: 303-312.[6] Moolenaar S H, Engelke U F, Wevers R A. Proton nuclear magnetic resonance spectroscopy of body fluids in the field of inborn errors of metabolism[J]. Ann Clin Biochem, 2003, 40(Pt 1): 16-24.[7] Lindon J C, Keun H C, Ebbels T M, et al. The consortium for metabonomic toxicology (COMET): aims, activities and achievements[J]. Pharmacogenomics, 2005, 6(7): 691-699.[8] Lindon J C, Nicholson J K, Holmes E, et al. Contemporary issues in toxicology the role of metabonomics in toxicology and its evaluation by the COMET project[J]. Toxicol Appl Pharm, 2003, 187(3): 137-146.[9] Bundy J G, Spurgeon D J, Svendsen C, et al. Earthworm species of the genus Eisenia can be phenotypically differentiated by metabolic profiling[J]. FEBS Lett, 2002, 521(1-3): 115-120.[10] Bundy J G, Lenz E M, Bailey N J, et al. Metabonomic assessment of toxicity of 4-fluoroaniline, 3,5-difluoroaniline and 2-fluoro-4-methylaniline to the earthworm Eisenia veneta (Rosa): identification of new endogenous biomarkers[J]. Environ Toxicol Chem, 2002, 21(9): 1 966-1 972.[11] Zhu Hang(朱航), Tang Hui-ru(唐惠儒), Zhang Xu(张许), et al. NMR-based metabonomics(基于NMR的代谢组学研究)[J]. Hua Xue Tong Bao(化学通报), 2006, 69: 1-9.[12] Yan Xian-zhong(颜贤忠), Zhao Jian-yu(赵剑宇), Peng Shuang-qing(彭双清), et al. Metabonomics in post-genomic era(代谢组学在后基因组时代的作用)[J]. Chinese J Magn Reson(波谱学杂志), 2004, 21(2): 263-271.[13] Vejchapipat P, Williams S R, Spitz L, et al. Intestinal metabolism after ischemia-reperfusion[J]. J Pediatr Surg, 2000, 35(5): 759-764.[14] Cheng L L, Chang I W, Smith B L, et al. Evaluating human breast ductal carcinomas with high-resolution magic-angle spinning proton magnetic resonance spectroscopy[J]. J Magn Reson, 1998, 135(1): 194-202.[15] Duarte I F, Stanley E G, Holmes E, et al. Metabolic assessment of human liver transplants from biopsy samples at the donor and recipient stages using high-resolution magic angle spinning 1H NMR spectroscopy[J]. Anal Chem, 2005, 77(17): 5 570-5 578.[16] Barton S J, Howe F A, Tomlins A M, et al. Comparison of in vivo 1H MRS of human brain tumours with 1H HR-MAS spectroscopy of intact biopsy samples in vitro[J]. Magma, 1999, 8(2): 121-128.[17] Griffin J L, Williams H J, Sang E, et al. Abnormal lipid profile of dystrophic cardiac tissue as demonstrated by one- and two-dimensional magic-angle spinning 1H NMR spectroscopy[J]. Magn Reson Med, 2001, 46(2): 249-255.[18] Waters N J, Holmes E, Waterfield C J, et al. NMR and pattern recognition studies on liver extracts and intact livers from rats treated with alpha-naphthylisothiocyanate[J]. Biochem Pharmacol, 2002, 64(1): 67-77.[19] Garrod S, Humpher E, Connor S C, et al. High-resolution 1H NMR and magic angle spinning NMR spectroscopic investigation of the biochemical effects of 2-bromoethanamine in intact renal and hepatic tissue\[J\]. Magn Reson Med, 2001, 45(5): 781-790.[20] Garrod S, Humpfer E, Spraul M, et al. High-resolution magic angle spinning 1H NMR spectroscopic studies on intact rat renal cortex and medulla[J]. Magn Reson Med, 1999, 41(6): 1 108-1 118.[21] Moka D, Vorreuther R, Schicha H, et al. Biochemical classification of kidney carcinoma biopsy samples using magic-angle-spinning 1H nuclear magnetic resonance spectroscopy\[J\]. J Pharm Biomed Anal, 1998, 17(1): 125-132.[22] Moka D, Vorreuther R, Schicha H, et al. Magic angle spinning proton nuclear magnetic resonance spectroscopic analysis of intact kidney tissue samples[J]. Anal Comm, 1997, 34: 107-109.[23] Tate A R, Foxall P J, Holmes E, et al. Distinction between normal and renal cell carcinoma kidney cortical biopsy samples using pattern recognition of 1H magic angle spinning (MAS) NMR spectra\[J\]. NMR Biomed, 2000, 13(2): 64-71.[24] Lucas L H, Wilson S F, Lunte C E, et al. Concentration profiling in rat tissue by high-resolution magic-angle spinning NMR spectroscopy: investigation of a model drug[J]. Anal Chem, 2005, 77(9): 2 978-2 984.[25] Chen Wen-xue(陈文学), Deng Feng(邓风), Yue Yong(岳勇). Applicationof NMR techniques to biological tissues(核磁共振技术在生物组织中的应用)[J]. Chinese J Magn Reson(波谱学杂志), 2004, 21(1): 127-139.[26] Cloarec O, Dumas M E, Craig A, et al. Statistical total correlation spectroscopy: an exploratory approach for latent biomarker identification from metabolic 1H NMR data sets[J]. Anal Chem, 2005, 77(5): 1 282-1 289.[27] Holmes E, Loo R L, Cloarec O, et al. Detection of urinary drug metabolite (xenometabolome) signatures in molecular epidemiology studies via statistical total correlation (NMR) spectroscopy\[J\]. Anal Chem, 2007, 79(7): 2 629-2 640.[28 ]Holmes E, Cloarec O, Nicholson J K. Probing latent biomarker signatures and in vivo pathway activity in experimental disease states via statistical total correlation spectroscopy (STOCSY) of biofluids: application to HgCl2 toxicity[J]. J Proteome Res, 2006, 5(6): 1 313-1 320.[29] Cloarec O, Campbell A, Tseng L H, et al. Virtual chromatographic resolution enhancement in cryoflow LC-NMR experiments via statistical total correlation spectroscopy[J]. Anal Chem, 2007, 79(9): 3 304-3 311. |