超极化气体肺部磁共振成像

波谱学杂志

超极化气体肺部磁共振成像

李海东^1,2，张智颖^1,2，韩叶清¹，孙献平¹，周欣^1*

1. 波谱与原子分子物理国家重点实验室，中国科学院生物磁共振分析重点实验室，武汉磁共振中心（中国科学院武汉物理与数学研究所），湖北武汉 430071；2. 中国科学院大学，北京 100049

收稿日期:2014-02-18 修回日期:2014-07-18 出版日期:2014-09-05 发布日期:2014-09-05
作者简介:李海东(1987-)，男，河南漯河人，博士研究生，无线电物理专业，主要研究方向为超极化气体肺部磁共振成像技术，E-mail: lihaidong1987@gmail.com. *通讯联系人：周欣，电话：027-87198802；E-mail:xinzhou@wipm.ac.cn. 周欣，1978 年9 月生，研究员，博士生导师．2004年获中国科学院武汉物理与数学研究所博士学位；2005~2007 年在美国哈佛大学和 Brigham 妇女医院从事博士后研究；2007~2009 年在美国能源部劳伦斯国家实验室和加州大学伯克利分校化学系任研究助理；2009 年入选中国科学院“百人计划”，2012 年任国家重大仪器专项首席科学家，2014 年获“湖北青年五四奖章”．主要研究方向为：用于磁共振医学成像和化学分析的超极化仪器研发、肺部MRI 方法和技术研究、超灵敏分子探针与分子影像学、原子磁力计和激光探测磁共振．
基金资助:
国家自然科学基金资助项目(81227902)，中国科学院“百人计划”资助项目([2010]88)，中国科学院知识创新工程重要方向资助项目(KJCX2-EW-N06)．

Lung MRI Using Hyperpolarized Gases

LI Hai-dong^1,2，ZHANG Zhi-ying^1,2，HAN Ye-qing¹，SUN Xian-ping¹，ZHOU Xin^1*

1. State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Key Laboratory of Magnetic Resonance in Biological Systems, National Center for Magnetic Resonance in Wuhan(Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences), Wuhan 430071, China;
2. University of Chinese Academy of Sciences, Beijing 100049, China

Received:2014-02-18 Revised:2014-07-18 Online:2014-09-05 Published:2014-09-05
About author:*Corresponding author：ZHOU Xin, Tel: 027-87198802, E-mail: xinzhou@wipm.ac.cn.
Supported by:
国家自然科学基金资助项目(81227902)，中国科学院“百人计划”资助项目([2010]88)，中国科学院知识创新工程重要方向资助项目(KJCX2-EW-N06)．

摘要/Abstract

摘要：

磁共振成像(MRI)技术具有非侵入、无放射性的特点，在临床疾病诊断中具有独特的优势，但是肺部空腔的特殊结构使传统质子MRI 无法对其直接成像．自旋交换光抽运(SEOP)方法可以使惰性气体原子的极化度增强4 个量级以上，从而使肺部的气体MRI 成为可能．该文介绍了超极化惰性气体肺部MRI 的最新研究进展，包括超极化气体磁共振相关参数的测量方法、肺部通气结构成像、肺部气体交换功能成像，同时比较了常用于肺部MRI气体的优点和缺点．

关键词: 肺部, 超极化气体, 自旋交换光抽运, 磁共振成像(MRI)

Abstract:

Magnetic resonance imaging (MRI) is a nonradioactive and noninvasive medical imaging technique, and it has been widely applied in the clinical diagnosis. However, using conventional proton MRI to obtain lung images is difficult, because the proton density in the lungs is about three orders of magnitude lower than that in other organs/tissues due to air cavities in the lungs. Hyperpolarized noble gases can be used as contrast agents for lung MRI. Spin-exchange optical pumping (SEOP) is a technique that can be used to enhance the nuclear spin polarizations of noble gases more than 10 000 folds, which makes noble gas lung MRI feasible. In this paper, the recent developments of hyperpolarized gases lung MRI were reviewed. Topics covered include comparison of different hyperpolarized noble gases used for lung MRI, unconventional methods for measuring quantitative parameters in hyperpolarized gas MRI, and the most updated applications of hyperpolarized gas MRI in assessing pulmonary structure and function.

Key words: lung, hyperpolarized gases, spin-exchange optical pumping, MRI

中图分类号:

O482.53

李海东1,2，张智颖1,2，韩叶清1，孙献平1，周欣1*. 超极化气体肺部磁共振成像[J]. 波谱学杂志.

LI Hai-dong1,2，ZHANG Zhi-ying1,2，HAN Ye-qing1，SUN Xian-ping1，ZHOU Xin1*. Lung MRI Using Hyperpolarized Gases[J]. Chinese Journal of Magnetic Resonance.

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