波谱学杂志 ›› 2004, Vol. 21 ›› Issue (2): 159-164.

• 研究论文 • 上一篇    下一篇

波段三维ESR成像系统的研制(Ⅴ)——灵敏度与分辨率实验及系统总性能指标

吴可1*,丛建波1,张清俊1,先宏1,王长振1,孙存普1, 郑莹光2,许静2,董凤霞2,沈尔中2,徐玉书2   

  1. 1. 军事医学科学院 放射医学研究所,国家生物医学分析中心自由基与顺磁共振实验室,北京 100850; 2.吉林大学 分析测试中心, 吉林 长春 130022
  • 收稿日期:2003-07-24 修回日期:2003-09-29 出版日期:2004-06-05 发布日期:2004-06-05
  • 基金资助:

    国家自然科学基金资助项目(29935080)

DEVELOPMENT OF L BAND THREE DIMENSIONAL ESR IMAGING SYSTEM(Ⅴ)——System Configuration and Performance Evaluation

WU Ke1*, CONG Jian-Bo1, ZHANG Qing-Jun1, XIAN Hong1, WANG Chang-Zhen1, SUN Cun-Pu1, ZHENG Ying-Guang2, XU Jing2, DONG Feng-Xia2, SHEN Er-Zhong2, XU Yu-Shu2   

  1. 1.Institute of Radiation Medicine, Academy of Military Medical Science, National Center of Biomedical Analgsis, FR&ESR Lab, Beijing 100850, China; 2.Analytic and Measure Center, Jilin University, Changchun 130022, China
  • Received:2003-07-24 Revised:2003-09-29 Online:2004-06-05 Published:2004-06-05
  • Supported by:

    国家自然科学基金资助项目(29935080)

摘要:

实验确定了自行研制的L波段三维电子自旋共振成像(3D-ESRI)系统的检测灵敏度及成像分辨率指标. 用Tempo水溶液模型测量灵敏度结果表明: 样品体积为10 mm, 高30 mm,测量浓度1×10-4 mol/L水溶液的信噪比为S/N=4∶1;加梯度磁场后,样品浓度需>5×10-4 mol/L,样品体积为19 mm, 高30 mm时,获得的投影谱的信噪比可满足图像重建的需要. 用DPPH固体样品确定的成像分辨率结果<1 mm.  文中还对ESRI系统的
各项总体性能做了归纳总结.

关键词: 电子自旋共振, 3D-ESR成像, 灵敏度, 分辨率, 性能指标

Abstract:

The detection sensitivity and the achievable spatial resolution of a newly developed L-band three-dimensional ESR imaging system were evaluated. The detection sensitivity was measured using a group of samples of aqueous Tempo solution. A signal to noise ratio (S/N) of about 4∶1 was obtained on a cylindric al sample with diameter of 10 mm and height of 30 mm, which corresponds to the minimum detectable concentration of 1×10-4 mol/L. To obtain projections with sufficient S/N for imaging, a higher concentration of more than 5×10-4 mol/L and a larger sample size (diameter of φ19 mm and height of 30 mm) was needed. Measured on solid DPPH samples, the spatial resolution of imaging can reach about 1 mm. The general performance features of the ESRI system were also discussed in the paper.

Key words: ESR, 3D-ESRI, sensitivity, resolution, performance feature

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