129Xe通气功能MRI与肺部病灶类型关联研究

doi:10.11938/cjmr20243103

波谱学杂志 ›› 2024, Vol. 41 ›› Issue (3): 276-285.doi: 10.11938/cjmr20243103

¹²⁹Xe通气功能MRI与肺部病灶类型关联研究

陈琪¹^,², 李海东¹^,², 方媛¹, 沈路阳¹, 刘无己¹^,², 罗明¹, 李业成¹^,², 张鸣¹^,², 赵修超¹^,², 石磊¹^,², 周倩¹, 韩叶清¹^,², 周欣¹^,²^,^*()

1.波谱与原子分子物理国家重点实验室，武汉磁共振中心，中国科学院精密测量科学与技术创新研究院，湖北武汉 430071
2.中国科学院大学，北京 100049

收稿日期:2024-03-23 出版日期:2024-09-05 在线发表日期:2024-04-09
通讯作者: *Tel: 027-87198631, E-mail: xinzhou@wipm.ac.cn.
基金资助:
国家自然科学基金项目(82127802);国家自然科学基金项目(21921004);国家自然科学基金项目(82372150);国家自然科学基金项目(82202119);国家重点研发计划项目(2018YFA0704000);国家重点研发计划项目(2022YFC2410-000);湖北省科技重大专项(2021ACA013);湖北省科技重大专项(2023BAA021);中国科学院重点项目(ZDBS-LY-JSC004);中国科学院重点项目(XDB0540000);中国科学院青年促进会项目(2020330);中国科学院青年促进会项目(2021330)

Association of ¹²⁹Xe Ventilation Functional MRI with Pulmonary Lesion Types

CHEN Qi¹^,², LI Haidong¹^,², FANG Yuan¹, SHEN Luyang¹, LIU Wuji¹^,², LUO Ming¹, LI Yecheng¹^,², ZHANG Ming¹^,², ZHAO Xiuchao¹^,², SHI Lei¹^,², ZHOU Qian¹, HAN Yeqing¹^,², ZHOU Xin¹^,²^,^*()

1. State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, National Center for Magnetic Resonance in Wuhan, Innovation Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences, Wuhan 430071, China
2. University of Chinese Academy of Sciences, Beijing 100049, China

Received:2024-03-23 Published:2024-09-05 Online:2024-04-09
Contact: *Tel: 027-87198631, E-mail: xinzhou@wipm.ac.cn.

摘要/Abstract

摘要：

本研究旨在探索¹²⁹Xe通气功能MRI与肺部病灶类型之间的关联．我们对143例患者进行¹²⁹Xe通气功能MRI和肺部CT扫描，并分析了肺叶水平的通气功能与肺部病灶类型之间的关系．结果显示，大部分肺叶（74.6%）¹²⁹Xe肺通气功能MRI和CT结果一致．通气功能损伤与CT病灶类型相关，且混合疾病和肺气肿/肺大疱更易引起肺通气功能障碍．此外，我们的研究显示不同肺部病灶类型会呈现出不同的通气模式．即¹²⁹Xe通气功能MRI和肺部CT能够提供互补信息．本研究的初步结果将为肺部病灶引起的通气功能损伤评估提供数据支持，为临床影像学诊断提供更多的参考依据，有助于优化肺部疾病的诊断和治疗．

关键词: 超极化¹²⁹Xe, 肺部通气功能磁共振成像, 肺部CT, 肺部疾病

Abstract:

This study investigates the correlation between ¹²⁹Xe ventilation functional MRI and CT-detected pulmonary lesion types. We performed ¹²⁹Xe ventilation functional MRI and CT scans on a sample of 143 patients, subsequently analyzing the relationship between lung ventilation function at the lobe level and CT lesion types. The findings suggest that the ventilation function from ¹²⁹Xe MRI was consistent with CT results in the majority of lung lobes (74.6%). The ventilation function impairment of lung correlates with CT lesion types, particularly in instances of mixed diseases and emphysema/bullae, which are more prone to induce lung ventilation dysfunction. Moreover, distinct ventilation patterns are observed among different lesion types. That is, the data from both ¹²⁹Xe ventilation functional MRI and CT provide complementary insights. The preliminary finding of this study offers data support for evaluating lung ventilation function caused by lung lesions, and provides more references for clinical imaging diagnosis, thereby contributing to the refinement of diagnostic and therapeutic strategies for pulmonary diseases.

Key words: hyperpolarized ¹²⁹Xe MRI, pulmonary ventilation functional MRI, lung CT, lung diseases

中图分类号:

O482.53

陈琪, 李海东, 方媛, 沈路阳, 刘无己, 罗明, 李业成, 张鸣, 赵修超, 石磊, 周倩, 韩叶清, 周欣. ¹²⁹Xe通气功能MRI与肺部病灶类型关联研究[J]. 波谱学杂志, 2024, 41(3): 276-285.

CHEN Qi, LI Haidong, FANG Yuan, SHEN Luyang, LIU Wuji, LUO Ming, LI Yecheng, ZHANG Ming, ZHAO Xiuchao, SHI Lei, ZHOU Qian, HAN Yeqing, ZHOU Xin. Association of ¹²⁹Xe Ventilation Functional MRI with Pulmonary Lesion Types[J]. Chinese Journal of Magnetic Resonance, 2024, 41(3): 276-285.

图/表 8

图1

表1

图2

表2

图3

图4

图5

图6

参考文献 25

[1]	EMAMI K, KADLECEK S J, WOODBURN J M, et al. Improved technique for measurement of regional fractional ventilation by hyperpolarized ³He MRI[J]. Magn Reson Med, 2010, 63(1): 137-150.
[2]	LOPES A J. Advances in spirometry testing for lung function analysis[J]. Expert Rev Respir Med, 2019, 13(6): 559-569.
[3]	OGUMA T, HIRAI T, NIIMI A, et al. Limitations of airway dimension measurement on images obtained using multi-detector row computed tomography[J]. PLoS One, 2013, 8(10): e76381.
[4]	DE BACKER J W, VOS W G, VINCHURKAR S C, et al. Validation of computational fluid dynamics in CT-based airway models with SPECT/CT[J]. Radiology, 2010, 257(3): 854-862. doi: 10.1148/radiol.10100322 pmid: 21084417
[5]	KERN A L, VOGEL-CLAUSSEN J. Hyperpolarized gas MRI in pulmonology[J]. Br J Radiol, 2018, 91(1084): 20170647.
[6]	WANG G X, YANG H Y, LI J, et al. Overview and progress of X-nuclei magnetic resonance imaging in biomedical studies[J]. Magn Reson Lett, 2023, 3(4): 327-343.
[7]	CHEN X M, ZHAO X C, SUN X P, et al. Study on the automatic accumulation-thawing device of hyperpolarized ¹²⁹Xe[J]. Chinese J Magn Reson, 2022, 39(3): 316-326.
	陈小明, 赵修超, 孙献平, 等. 超极化¹²⁹Xe自动收集-升华装置研究[J]. 波谱学杂志, 2022, 39(3): 316-326. doi: 10.11938/cjmr20222998
[8]	DRIEHUYS B, MARTINEZ-JIMENEZ S, CLEVELAND Z I, et al. Chronic obstructive pulmonary disease: safety and tolerability of hyperpolarized ¹²⁹Xe MR imaging in healthy volunteers and patients[J]. Radiology, 2012, 262(1): 279-289.
[9]	SHUKLA Y, WHEATLEY A, KIRBY M, et al. Hyperpolarized ¹²⁹Xe magnetic resonance imaging: tolerability in healthy volunteers and subjects with pulmonary disease[J]. Acad Radiol, 2012, 19(8): 941-951.
[10]	MCINTOSH M J, KOONER H K, EDDY R L, et al. Asthma control, airway mucus, and ¹²⁹Xe MRI ventilation after a single benralizumab dose[J]. Chest, 2022, 162(3): 520-533.
[11]	KOONER H K, MCINTOSH M J, MATHESON A M, et al. Postacute COVID-19 Syndrome: ¹²⁹Xe MRI Ventilation Defects and Respiratory Outcomes 1 Year Later[J]. Radiology, 2023, 307(2): e222557.
[12]	LI H D, ZHAO X C, WANG Y J, et al. Damaged lung gas exchange function of discharged COVID-19 patients detected by hyperpolarized ¹²⁹Xe MRI[J]. Sci Adv, 2021, 7(1): eabc8180.
[13]	ZHOU Q, RAO Q, LI H D, et al. Evaluation of injuries caused by coronavirus disease 2019 using multi-nuclei magnetic resonance imaging[J]. Magn Reson Lett, 2021, 1(1): 2-10. doi: 10.1016/j.mrl.2021.100009 pmid: 35673615
[14]	XIE H Y, ZHAO Z, ZHANG W J, et al. Quantitative analysis of lung function and airway remodeling using ventilation/perfusion single photon emission tomography/computed tomography and HRCT in patients with chronic obstructive pulmonary disease and asthma[J]. Ann Nucl Med, 2023, 37(9): 504-516. doi: 10.1007/s12149-023-01848-7 pmid: 37268867
[15]	EIBSCHUTZ L S, RABIEE B, ASADOLLAHI S, et al. FDG-PET/CT of COVID-19 and Other Lung Infections[J]. Semin Nucl Med, 2022, 52(1): 61-70.
[16]	MATIN T N, RAHMAN N, NICKOL A H, et al. Chronic obstructive pulmonary disease: lobar analysis with hyperpolarized ¹²⁹Xe MR imaging[J]. Radiology, 2017, 282(3): 857-868.
[17]	EDDY R L, SVENNINGSEN S, KIRBY M, et al. Is computed tomography airway count related to asthma severity and airway structure and function?[J]. Am J Respir Crit Care Med, 2020, 201(8): 923-933.
[18]	FAIN S B, GONZALEZ-FERNANDEZ G, PETERSON E T, et al. Evaluation of structure-function relationships in asthma using multidetector CT and hyperpolarized ³He MRI[J]. Acad Radiol, 2008, 15(6): 753-762.
[19]	AGUSTí A, CELLI B R, CRINER G J, et al. Global initiative for chronic obstructive lung disease 2023 report: GOLD executive summary[J]. Eur Respir J, 2023, 61(4): 2300239.
[20]	DE LANGE E E, ALTES T A, PATRIE J T, et al. Evaluation of asthma with hyperpolarized helium-3 MRI: correlation with clinical severity and spirometry[J]. Chest, 2006, 130(4): 1055-1062. doi: 10.1378/chest.130.4.1055 pmid: 17035438
[21]	VIRGINCAR R S, CLEVELAND Z I, KAUSHIK S S, et al. Quantitative analysis of hyperpolarized ¹²⁹Xe ventilation imaging in healthy volunteers and subjects with chronic obstructive pulmonary disease[J]. NMR Biomed, 2013, 26(4): 424-435.
[22]	CAREY K J, HOTVEDT P, MUMMY D G, et al. Comparison of hyperpolarized ³He-MRI, CT based parametric response mapping, and mucus scores in asthmatics[J]. Front Physiol, 2023, 14: 1178339.
[23]	COCCONCELLI E, BERNARDINELLO N, GIRAUDO C, et al. Characteristics and prognostic factors of pulmonary fibrosis after COVID-19 pneumonia[J]. Front Med (Lausanne), 2021, 8: 823600.
[24]	XIE R L, WANG Y, ZHAO Y N, et al. Lung nodule pre-diagnosis and insertion path planning for chest CT images[J]. BMC Med Imaging, 2023, 23(1): 22.
[25]	DODD J D, LAVELLE L P, FABRE A, et al. Imaging in cystic fibrosis and non cystic fibrosis bronchiectasis[J]. Semin Resp Crit Care, 2015, 36(2): 194-206.

基本信息	CT异常（n=123）	CT正常（n=20）
年龄	57.5 ± 12.7	43.3 ± 13.4
男性人数	79 (64.2%)	13 (65.0%)
BMI	24.8 ± 3.4	24.3 ± 3.2
PFTs
FEV_1%pred	105.0 ± 14.4	107.3 ± 12.8
FVC_%pred	107.3 ± 14.1	112.5 ± 13.3
FEV₁/FVC_%pred	94.9 ± 6.0	95.2 ± 4.8
RV_%pred	86.7 ± 22.8	102.6 ± 20.2
TLC_%pred	89.9 ± 12.6	96.8 ± 8.8
RV/TLC_%pred	93.8 ± 18.5	104.8 ± 16.3
FRC_%pred	100.5 ± 22.1	112.7 ± 12.1
PEF_%pred	111.7 ± 22.0	99.0 ± 17.1
呼吸问卷
SGRQ评分	12.0 ± 13.7	8.8 ± 10.9
¹²⁹Xe MRI
全局VDP(%)	4.6 ± 3.0	3.2 ± 1.6

	CT(0)-¹²⁹Xe MRI(0)	CT(0)-¹²⁹Xe MRI(1)	CT(1)-¹²⁹Xe MRI(0)	CT(1)-¹²⁹Xe MRI(1)
RUL	54（37.8%）	16（11.1%）	15（10.5%）	58（40.6%）
RML	74（51.7%）	13（9.1%）	18（12.6%）	38（26.6%）
RLL	43（30.0%）	7（4.9%）	32（22.4%）	61（42.7%）
LUL	49（34.3%）	32（22.3%）	10（7.0%）	52（36.4%）
LLL	53（37.1%）	18（12.6%）	21（14.7%）	51（35.7%）
总计	273（38.2%）	86（12.0%）	96（13.4%）	260（36.4%）

¹²⁹Xe通气功能MRI与肺部病灶类型关联研究

Association of ¹²⁹Xe Ventilation Functional MRI with Pulmonary Lesion Types

RichHTML

PDF

可视化

摘要/Abstract

引用本文

使用本文

图/表 8

参考文献 25

相关文章 4

编辑推荐

Metrics

本文评价

[1]	陈小明, 赵修超, 孙献平, 谢军帅, 李海东, 韩叶清, 刘小玲, 陈琪, 周欣. 超极化¹²⁹Xe自动收集-升华装置研究[J]. 波谱学杂志, 2022, 39(3): 316-326.
[2]	王崇武,黄曦,石磊,陈世桢,周欣. 组织蛋白酶B响应的超极化¹²⁹Xe MRI探针对肺癌细胞的超灵敏探测[J]. 波谱学杂志, 2021, 38(3): 336-344.
[3]	袁晨露, 郭茜旎, 陈世桢, 周欣. 新型葫芦[6]脲纳米颗粒超极化¹²⁹Xe“分子笼”研究[J]. 波谱学杂志, 2019, 36(4): 472-480.
[4]	张继1,2，罗晴1，郭茜旎1，陈世桢1，周欣1*. 超极化¹²⁹Xe磁共振分子影像学[J]. 波谱学杂志, 2013, 30(2): 279-292.