脑科学研究中的质子磁共振波谱方法

doi:10.11938/cjmr20182702

摘要/Abstract

摘要： 核磁共振（NMR）波谱作为一种操作简单、高效且重复性良好的技术手段，在脑科学领域的应用日益广泛，尤其是离体核磁共振氢谱（¹H NMR）和活体核磁共振氢谱（¹H MRS）.¹H NMR和¹H MRS在实验设计、样品预处理、数据处理等方面各有优劣、各擅胜场.本综述主要从适用范围、样品预处理、数据处理分析等方面，对二者在方法学层面的研究现状进行总结和讨论，以期为脑科学领域的研究者进行大脑代谢相关研究时提供一定的参考和帮助.

关键词: 核磁共振波谱, 活体谱, 脑科学, 代谢

Abstract: Nuclear magnetic resonance spectroscopy, especially in vivo proton magnetic resonance spectrum (¹H MRS) and proton nuclear magnetic resonance (¹H NMR), has been increasingly used in brain science researches. There are pros and cons in ¹H MRS and ¹H NMR with respect to experiment design, sample preparation and data processing. In this review, we summarized and discussed the recent progresses of these two techniques in the ends of application range, sample preparation, quantification and data analysis. The work will provide a reference and insights for neuroscience researchers who are interested in using magnetic resonance spectroscopy for metabolic studies of the brain.

Key words: nuclear magnetic resonance spectroscopy, in vivo spectrum, brain science, metabolism

中图分类号:

O482.53

刘涛涛, 王杰, 郭向阳. 脑科学研究中的质子磁共振波谱方法[J]. 波谱学杂志, 2020, 37(2): 232-240.

LIU Tao-tao, WANG Jie, GUO Xiang-yang. Proton Magnetic Resonance Spectroscopy in Brain Science Researches[J]. Chinese Journal of Magnetic Resonance, 2020, 37(2): 232-240.

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