光激活磁共振脑功能成像的研究现状及前景

波谱学杂志

光激活磁共振脑功能成像的研究现状及前景

吴瑞琪^1,3，李博^1,3，刘悦²，徐富强^1,2*

1. 波谱与原子分子物理国家重点实验室(中国科学院武汉物理与数学研究所)，湖北武汉 430071；2. 武汉光电国家实验室，湖北武汉430074；3. 中国科学院大学，北京 100049

收稿日期:2013-06-27 修回日期:2013-07-17 出版日期:2014-06-05 发布日期:2014-06-05
作者简介:吴瑞琪(1987-)，女，江西抚州人，博士研究生，专业为无线电物理． *通讯联系人：徐富强，电话：027-87197091，E-mail：fuqiang.xu@wipm.ac.cn.
基金资助:
国家自然科学基金资助项目(91132307/H09, 31171061/C090208和20921004), 国家科技部支撑计划资助项目(2012BAI23B02)．

Current State and Future of Optogenetic Functional Magnetic Resonance Imaging

WU Rui-qi^1,3，LI Bo^1,3，LIU Yue²，XU Fu-qiang^1,2*

1. State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics (Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences), Wuhan 430071, China; 2. Wuhan National Laboratory of Optoelectronics, Wuhan 430074, China; 3. University of Chinese Academy of Sciences, Beijing 100049, China

Received:2013-06-27 Revised:2013-07-17 Online:2014-06-05 Published:2014-06-05
About author:*Corresponding author：XU Fu-qiang, Tel: 027-87197091. E-mail: fuqiang.xu@wipm.ac.cn.
Supported by:
国家自然科学基金资助项目(91132307/H09, 31171061/C090208和20921004), 国家科技部支撑计划资助项目(2012BAI23B02)．

摘要/Abstract

摘要：

磁共振脑功能成像经过20年的发展已经成为大脑认知神经科学研究中最主要的技术．光激活磁共振脑功能成像是将它与新发展起来的光遗传学相结合的新兴技术，具有高时空选择性地分析特定神经回路或特定类型的神经元在整个功能网络中的作用的巨大潜力，为理解人类脑功能和揭示神经精神疾病机理可提供新的技术手段．

关键词: 磁共振脑功能成像(fMRI), 光遗传学, 血氧水平依赖, 功能连接

Abstract:

Functional magnetic resonance imaging (fMRI) is the mainstay of neuroimaging approach in neuroscience after a rapid development during the past twenty years. The optogenetic fMRI (ofMRI) is a novel technology that combines optogenetics and fMRI, which has the potential to be used to analyze the functional roles and properties of specific neurons and/or specific neurocircuits in the whole brain. It opens a new vista for exploring human brain networks both functionally and structurally.

Key words: functional magnetic resonance image, optogenetics, blood oxygen level dependent, functional connectivity

中图分类号:

O482.53

吴瑞琪1,3，李博1,3，刘悦2，徐富强1,2*. 光激活磁共振脑功能成像的研究现状及前景[J]. 波谱学杂志.

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