人脑GABA测量在临床3 T磁共振成像系统上的实现

波谱学杂志

人脑GABA测量在临床3 T磁共振成像系统上的实现

陈录广，李建奇*，王前锋

华东师范大学物理系，上海市磁共振重点实验室，上海 200062

收稿日期:2012-10-22 修回日期:2012-11-28 出版日期:2013-09-05 发布日期:2013-09-05
作者简介:陈录广（1986-），男，安徽人，硕士研究生，研究方向为无线电物理. *通讯联系人：李建奇，电话：021-62223871，E-mail：jqli@phy.ecnu.edu.cn.
基金资助:
上海市科委基础研究重点资助项目(10JC1414600)，国家自然科学基金资助项目(81271533).

Detection of GABA in Human Brain on Clinical 3 T MRI Scanner

CHEN Lu-guang，LI Jian-qi*，WANG Qian-feng

Shanghai Key Laboratory of Magnetic Resonance Imaging, Department of Physics, East China Normal University, Shanghai 200062, China

Received:2012-10-22 Revised:2012-11-28 Online:2013-09-05 Published:2013-09-05
About author:*Corresponding author: Li Jian-qi, Tel: 021-62223871, E-mail: jqli@phy.ecnu.edu.cn.
Supported by:
上海市科委基础研究重点资助项目(10JC1414600)，国家自然科学基金资助项目(81271533).

摘要/Abstract

摘要：

γ-氨基丁酸(γ-Aminobutyric Acid，GABA)是人脑中枢神经系统中一种重要的抑制性神经递质，对神经活动的调节起着主导作用.由于人脑GABA固有含量低以及与其他代谢物谱峰的重叠，在临床用磁共振成像系统中使用点分辨波谱(PRESS)序列或受激回波采集模式(STEAM)序列难以直接检测到GABA δ 3.01信号. 该文报道了MEGA-PRESS脉冲序列在临床用3 T磁共振成像系统上的实现，采用J差分谱编辑技术实现了对GABA的检测. 水模实验和人脑在体实验显示，MEGA-PRESS序列对GABA δ 3.01信号具有较好的检测效果.

关键词: γ-氨基丁酸(GABA), J差分, 谱编辑, MEGA-PRESS

Abstract:

GABA (γ-aminobutyric acid) is a major inhibitory neurotransmitter in the central nervous system of human brain, and plays a predominant role in the regulation of neuronal activity. Detection of GABA by in vivo magnetic resonance spectroscopy is hindered by its inherent low concentration and overlapping with resonances from other metabolites. GABA cannot be directly detected with the PRESS (point resolved echo spectroscopy) or STEAM (stimulated echo acquisition mode) pulse sequences on the clinical MRI scanners. This paper reported the implementation of a single-voxel spectroscopy J-difference editing sequence (MEGA-PRESS) for detection of GABA. The results from phantom studies and human brain indicated that it is feasible to use MEGAPRESS for detection of GABA on 3 T clinical MRI scanners.

Key words: GABA, J-difference, spectral editing, MEGA-PRESS

中图分类号:

O482. 53

陈录广，李建奇*，王前锋. 人脑GABA测量在临床3 T磁共振成像系统上的实现[J]. 波谱学杂志.

CHEN Lu-guang，LI Jian-qi*，WANG Qian-feng. Detection of GABA in Human Brain on Clinical 3 T MRI Scanner[J]. Chinese Journal of Magnetic Resonance.

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