波谱学杂志 ›› 2009, Vol. 26 ›› Issue (2): 188-196.

• 研究论文 • 上一篇    下一篇

新型饱和烷基类自由基捕捉剂的合成及ESR研究

赵吉寿1*; 禇玉洁1,2; 杜立波2; 韩璐2; 姚同伟3; 何超1; 王伟军1; 田秋2; 贾宏瑛2; 刘扬2*   

  1. (1.云南民族大学 化学与生物技术学院 民族药国家重点实验室,云南 昆明 650031;
    2.中国科学院 化学研究所 分子动态与稳态结构国家重点实验室,北京 100190;3.北京化工大学 理学院,北京 100029 )
  • 收稿日期:2008-11-24 修回日期:2008-12-27 出版日期:2009-06-05 发布日期:2009-12-05
  • 通讯作者: 赵吉寿; 刘扬

Syntheses and Spin Trapping-ESR Studies of Novel Saturated Alkyl Spin-traps

ZHAO Ji-shou1*; CHU Yu-jie1,2; DU Li-Bo2; HAN Lu2; YAO Tong-wei3; 
HE Chao1; WANG Wei-jun1; TIAN Qiu2; JIA Hong-ying2; LIU Yang2*
  

  1. (1.State Key Laboratory of Ethnic Medicine, College of Chemistry and Biotechnology, Yunnan Nationalities University, Kunming 650031, China;
    2.State Key Laboratory for Structural Chemistry of Unstable and Stable Species, Institute of Chemistry, Chinese Academy of Science, Beijing 100190, China; 3.Faculty of Sciences, Beijing University of Chemical Technology, Beijing 100029, China)
  • Received:2008-11-24 Revised:2008-12-27 Online:2009-06-05 Published:2009-12-05
  • Contact: ZHAO Ji-Shou; LIU Yang

摘要: 设计合成了新的饱和烷基类线型硝酮捕捉剂N-(亚乙基)-t-丁胺-N-氧化物(EBN)和N-(亚乙基)-1-二乙氧基磷酰基-1-甲基乙基胺N-氧化物(EPN),并运用ESR、MS、IR、UV等一系列手段对其结构进行了表征,同时对Fenton体系中产生的羟基及不同类型的氧中心、碳中心和硫中心自由基的捕获能力进行了系统的研究. 结果表明,这两种捕捉剂合成方法比较简单,产率较高,对羟基等自由基有比较强的捕捉能力. 期望本文的工作能为自由基捕捉剂的研究提供一个新的思路.

关键词: 硝酮捕捉剂, 电子自旋共振(ESR), EBN, EPN, 自由基

Abstract: Two new saturated alkyl linear nitrone spin-traps [N-(Ethylidene)-t- butylamine N-oxide] (EBN) and (N-(Ethylidene)-1-diethoxyphosphoryl-1- methylethylamine -Oxide) (EPN) were synthesized. Characterization of the structures of these spin traps were carried out using NMR, MS, IR, UV and other means. The two compounds were shown to be able to trap hydroxyl radicals produced in the Fenton reaction and carbon-, oxygen- or sulfur- entered radicals.

Key words: electron-spin resonance (ESR), nitrone spin trap, EBN, EPN, radicals

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