新药炎琥宁的碳氢NMR信号全归属

波谱学杂志 ›› 2006, Vol. 23 ›› Issue (2): 247-251.

新药炎琥宁的碳氢NMR信号全归属

沈阳药科大学分析测试中心，辽宁沈阳 110016

收稿日期:2005-05-16 修回日期:2005-11-21 出版日期:2006-06-05 发布日期:2006-06-05

Assignment of ¹³C and ¹H Chemical Shifts of Potassium Sodium Dehydroandrographolide Succinate

Center of Instrumental Analysis, Shenyang Pharmaceutical University, Shenyang 110016, China

Received:2005-05-16 Revised:2005-11-21 Online:2006-06-05 Published:2006-06-05

摘要/Abstract

摘要：

炎琥宁为中药提取物穿心莲内酯经结构改造后获得的一个抗菌、抗病毒新药，本文应用1D NMR和脉冲梯度场2D NMR实验技术（gCOSY，gHSQC，gHSQC-TOCOSY，gHMBC）对其结构进行了研究，并首次对其¹H NMR、¹³C NMR谱信号进行了全归属.

关键词: 2D NMR技术, 碳氢NMR信号全归属, 炎琥宁

Abstract:

Potassium sodium dehydroandrographolide succinate (PSDS) is a new antibacterial and antiviral agent derived from andrographolide, a compound found in the extract of medicinal herb Andrographis paniculata (Burm. f.) Nees. In this study, the ¹³C and ¹H chemical shifts of the compound were assigned using 1D NMR and 2D NMR techniques including gCOSY, gHSQC, gHSQC-TOCOSY and gHMBC. Its structure was determined from the NMR data.

Key words: 2D NMR, chemical shift assignments, potassium sodium dehydroandrographolide succinate, andrographolide

中图分类号:

O561.1

李文, 沙沂, 魏建玲, 高慧媛, 吴立军. 新药炎琥宁的碳氢NMR信号全归属[J]. 波谱学杂志, 2006, 23(2): 247-251.

LI Wen, SHA Yi, WEI Jian-Ling, GAO Hui-Yuan, WU Li-Jun-. Assignment of ¹³C and ¹H Chemical Shifts of Potassium Sodium Dehydroandrographolide Succinate[J]. Chinese Journal of Magnetic Resonance, 2006, 23(2): 247-251.

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