DTPA双芳酰胺钆配合物作为肝胆磁共振成象造影剂

波谱学杂志 ›› 1998, Vol. 15 ›› Issue (3): 217-222.

DTPA双芳酰胺钆配合物作为肝胆磁共振成象造影剂

文杰, 卓仁禧, 王路

国家教委生物医用高分子材料实验室, 武汉大学化学系, 武汉 430072

收稿日期:1998-01-19 修回日期:1998-02-23 出版日期:1998-06-05 发布日期:2018-01-13
作者简介:文杰,男,26岁,博士研究生
基金资助:
国家自然科学基金,国家教委博士点基金

AROMATIC DTPA-BIS(AMIDE) GADOLINIUM COMPLEXES AS HEPATOBILIARY CONTRAST AGENTS FOR MAGNETIC RESONANCE IMAGING

Wen Jie, Zhuo Renxi, Wang Lu

Laboratory of Biomedical Polymer Materials of the State Education Commission of China, Department of Chemistry, Wuhan University, Wuhan 430072

Received:1998-01-19 Revised:1998-02-23 Online:1998-06-05 Published:2018-01-13

摘要/Abstract

摘要： 对三种DTPA双芳酰胺钆配合物用作肝胆磁共振成象造影剂进行了研究.配合物的亲脂性通过正辛醇-水分配比进行表征,结果表明实验值与理论值有很好的线性关系.蛋白结合实验表明亲脂性较强的配合物具有较强的蛋白结合能力.家兔的活体磁共振成象表明,将芳香环引入配合物中可以实现肝细胞对配合物的特异性摄取.

关键词: 磁共振成象造影, DTPA双芳酰胺, 肝胆造影剂, 钆

Abstract: Three aromatic DTPA-bis(amide) gadolinium complexes have been investigated for use as hepatobiliary contrast agents for magnetic resonance imaging. The lipophilicity of the complexes was determined by means of octanol-buffer partition coefficient. The measured and theoretical lipophilicity exhibited good correlation. Protein binding studies show that the more lipophilic complex has higher BSA binding affinity. T₁-weighted spin-echo images of rabbits demonstrated hepatobiliary specific uptake and excretion could also be achieved by adding aromatic rings to the molecule of a paramagnetic complex and were sensitive to the substituents on the aromatic rings.

Key words: Magnetic resonance imaging, Aromatic DTPA-bis (amide), Hepatobiliary contrast agents, Gadolinium

文杰, 卓仁禧, 王路. DTPA双芳酰胺钆配合物作为肝胆磁共振成象造影剂[J]. 波谱学杂志, 1998, 15(3): 217-222.

Wen Jie, Zhuo Renxi, Wang Lu. AROMATIC DTPA-BIS(AMIDE) GADOLINIUM COMPLEXES AS HEPATOBILIARY CONTRAST AGENTS FOR MAGNETIC RESONANCE IMAGING[J]. Chinese Journal of Magnetic Resonance, 1998, 15(3): 217-222.

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