DTPA双酯Gd (Ⅲ)配合物的合成及其弛豫率

波谱学杂志 ›› 1997, Vol. 14 ›› Issue (4): 347-352.

DTPA双酯Gd (Ⅲ)配合物的合成及其弛豫率

柏正武, 卓仁禧

武汉大学化学系, 国家教委生物医用高分子材料开放实验室, 武汉 430072

收稿日期:1997-01-28 修回日期:1997-03-31 出版日期:1997-08-05 发布日期:2018-01-22
作者简介:柏正武,男,34岁,博士,现为同济医科大学博士后
基金资助:
国家“863”高科技项目

SYNTHESIS AND RELAXIVITY OF DTPA DIESTER Gd(Ⅲ) COMPLEXES

Bai Zhengwu, Zhuo RenXi

Department of Chemistry, Wuhan University, Laboratory of Biomedical Polymer Materials of the State Education Commission, Wuhan 430072

Received:1997-01-28 Revised:1997-03-31 Online:1997-08-05 Published:2018-01-22

摘要/Abstract

摘要： 二乙三胺五乙酸双酐与甘醇单醚反应,得到含多氨基多羧基双酯配体,配体与GdCl₃·6H₂O反应生成非离子配合物.配体及配合物用IR、¹H NMR和元素分析进行了表征,并测试了配合物的驰豫率,其中3种配合物的弛豫率比已用于临床诊断的Gd (DTPA)强,

关键词: 磁共振成象造影剂, 钆配合物, 驰豫率

Abstract: Polyaminocarboxylate ligands were synthesized by the reaction of diethylenetriaminepentaacetic dianhydride with glycol monoether, and their Gd(Ⅲ) complexes were also prepared. The structures of the ligands and complexes were confirmed by IR, ¹H NMR spectra and elemental anaJysis. The relaxivity of these Gd(Ⅲ) complexes were investigated and the data indicated that three of them showed higher relaxivity as compared to Gd(DTPA).

Key words: MRI contrast agent, Gadolinium complex, Relaxivity

柏正武, 卓仁禧. DTPA双酯Gd (Ⅲ)配合物的合成及其弛豫率[J]. 波谱学杂志, 1997, 14(4): 347-352.

Bai Zhengwu, Zhuo RenXi. SYNTHESIS AND RELAXIVITY OF DTPA DIESTER Gd(Ⅲ) COMPLEXES[J]. Chinese Journal of Magnetic Resonance, 1997, 14(4): 347-352.