波谱学杂志 ›› 1987, Vol. 4 ›› Issue (3): 229-231.

• 研究论文 • 上一篇    下一篇

1N-HMR方法测定1-乙基-7-氯-6-氟-1.4-二氢-4-氧喹啉-3-羧酸乙酯与其异构体的相对含量

郭惠元, 顾慧儿, 张忠岳, 孙兰英   

  1. 中国医学科学院抗菌素研究所 北京
  • 收稿日期:1986-11-17 修回日期:1987-01-06 出版日期:1987-09-05 发布日期:2018-01-22

DETERMINATION OF RELATIVE CONTENTS OF ETHYL 7-CHLORO-1-ETHYL-6-FLUORO-1, 4-DIHYDRO-4-OXOQUINOLINE-3-CARBOXYLATE AND ITS ISOMER BY 1H NMR METHOD

Guo Huiyuan, Gu Huier, Zhang Zhongyue, Sun Lanying   

  1. Institute of Antibiotics, Chinese Academy of Medical Sciences, Beijing
  • Received:1986-11-17 Revised:1987-01-06 Online:1987-09-05 Published:2018-01-22

摘要: 本文报道用1H-NMR技水,采用峰高和积分两种方法测定了1-乙基-7-氯-6-氟-1.4二氢-4-氧喹啉-3-羧酸乙酯与其异构体的相对含量,并对这两种方法进行了讨论。

Abstract: In this paper the utilization of 1H NMR including both peak height and integration determination methods is reported in the estimation of the relative contents of ethyl 7-chloro-l-ethyl-6-fluoro-1.4-dihydro-4-oxoquinoline-3-carboxyla-te and its 5-chloro isomer which were produced in the cyclization reaction of di-ethyl 3-chloro-4-fluoroanilinemethylene-malonate in the presence of different Lewis acids.