基于原子磁力计的穿戴式脑磁图动态测量研究

doi:10.11938/cjmr20222975

波谱学杂志 ›› 2022, Vol. 39 ›› Issue (3): 337-344.doi: 10.11938/cjmr20222975

基于原子磁力计的穿戴式脑磁图动态测量研究

陈春巧^1,^2,³,张欣^2,³,郭清乾^2,³,徐佳玉^1,²,冯晓宇^2,³,常严^2,³,胡涛^2,^3,*(),杨晓冬^1,^2,^3,*()

1. 长春理工大学电子信息工程学院，吉林长春 130022
2. 中国科学院苏州生物医学工程技术研究所，江苏苏州 215163
3. 季华实验室，广东佛山 528200

收稿日期:2022-02-15 出版日期:2022-09-05 发布日期:2022-03-25
通讯作者: 胡涛,杨晓冬 E-mail:hutao@sibet.ac.cn;xiaodong.yang@sibet.ac.cn
基金资助:
苏州市基础研究试点项目(SJC2021024);季华实验室项目(X190131TD190);江苏省自然科学基金青年项目(BK20200215)

Moving Wearable Magnetoencephalography Measurement Study Based on Optically-pumped Magnetometer

Chun-qiao CHEN^1,^2,³,Xin ZHANG^2,³,Qing-qian GUO^2,³,Jia-yu XU^1,²,Xiao-yu FENG^2,³,Yan CHANG^2,³,Tao HU^2,^3,*(),Xiao-dong YANG^1,^2,^3,*()

1. School of Electronic and Information Engineering, Changchun University of Science and Technology, Changchun 130022, China
2. Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou 215163, China
3. Jihua Laboratory, Foshan 528200, China

Received:2022-02-15 Online:2022-09-05 Published:2022-03-25
Contact: Tao HU,Xiao-dong YANG E-mail:hutao@sibet.ac.cn;xiaodong.yang@sibet.ac.cn

1. 附件材料.pdf(567KB)

摘要/Abstract

摘要：

脑磁图作为一种无创的脑功能成像技术，依靠超高的时间及空间溯源分辨率，在脑科学研究和临床应用领域中有着极其重要的价值.本文介绍了自主搭建的基于原子磁力计的穿戴式脑磁图系统，通过设计匀场补偿线圈组并结合参考传感器阵列，实现被试头部运动区域内剩磁在±1 nT以内，保证动态测量过程中传感器输出维持在动态范围以内；同时提出了一种虚拟合成梯度去噪方法，显著抑制了环境共模噪声；最终在被试者头部自然运动状态下，成功检测到高信噪比的α节律信号与听觉诱发磁场信号，证实了该系统的有效性，为穿戴式脑磁图应用推广提供更多的可能性.

关键词: 穿戴式脑磁图, 原子磁力计, 动态测量, 匀场补偿, 噪声抑制

Abstract:

Magnetoencephalography is a non-invasive technology for brain function imaging, which is of enormous value to brain science research and clinical application due to its ultra-high temporal and spatial trace resolution. In this paper, we introduce a self-built and atomic magnetometer based wearable magnetoencephalography system. By designing bi-planar coils system and combining with reference sensor array, the residual magnetic field in the subject's head movement area is controlled to be within ±1 nT, which ensures the sensors are maintained within their dynamic range during the moving measurement. At the same time, a virtual gradiometer-based noise reduction method is proposed to suppress the common-mode magnetic-field noise. Finally, the alpha rhythm and auditory evoked magnetic field signals with high signal-to-noise ratio are successfully detected under the subject's natural head movement and the effectiveness of the system is confirmed. This study could provide more possibilities for the application and promotion of moving wearable magnetoencephalography.

Key words: wearable magnetoencephalography, optically-pumped magnetometer, moving measurement, field nulling, noise reduction

中图分类号:

O441.5
Q64

陈春巧,张欣,郭清乾,徐佳玉,冯晓宇,常严,胡涛,杨晓冬. 基于原子磁力计的穿戴式脑磁图动态测量研究[J]. 波谱学杂志, 2022, 39(3): 337-344.

Chun-qiao CHEN,Xin ZHANG,Qing-qian GUO,Jia-yu XU,Xiao-yu FENG,Yan CHANG,Tao HU,Xiao-dong YANG. Moving Wearable Magnetoencephalography Measurement Study Based on Optically-pumped Magnetometer[J]. Chinese Journal of Magnetic Resonance, 2022, 39(3): 337-344.

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	匀场线圈			一阶梯度线圈
	B_x	B_y	B_z	dB_z/d_x	dB_z/d_y	dB_z/d_z	dB_y/d_x
补偿线圈系数	1.37 nT/mA	1.84 nT/mA	9.74 nT/mA	11.62 nT/m/mA	13.17 nT/m/mA	52.24 nT/m/mA	5.22 nT/m/mA

基于原子磁力计的穿戴式脑磁图动态测量研究

Moving Wearable Magnetoencephalography Measurement Study Based on Optically-pumped Magnetometer

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