SPATIALLY-LOCALIZED SCAFFOLD PROTEINS MAY FACILITATE TO TRANSMIT LONG-RANGE SIGNALS

doi:10.1016/S0252-9602(10)60008-2

数学物理学报(英文版) ›› 2009, Vol. 29 ›› Issue (6): 1657-1669.doi: 10.1016/S0252-9602(10)60008-2

SPATIALLY-LOCALIZED SCAFFOLD PROTEINS MAY FACILITATE TO TRANSMIT LONG-RANGE SIGNALS

Xinfeng Liu, Qing Nie

Department of Mathematics, University of South Carolina, Columbia, SC 29208, USA|Department of Mathematics, Center for Mathematical and Computational Biology, University of California, Irvine, CA 92697, USA

收稿日期:2009-10-28 出版日期:2009-11-20 发布日期:2009-11-20
基金资助:
This work was supported by the NSF/NIH initiative on Mathematical Biology through R01GM75309 and R01GM67247 from the National Institute of General Medical Sciences, and by NIH P50GM76516 and NSF DMS0917492.

SPATIALLY-LOCALIZED SCAFFOLD PROTEINS MAY FACILITATE TO TRANSMIT LONG-RANGE SIGNALS

Xinfeng Liu, Qing Nie

Department of Mathematics, University of South Carolina, Columbia, SC 29208, USA|Department of Mathematics, Center for Mathematical and Computational Biology, University of California, Irvine, CA 92697, USA

Received:2009-10-28 Online:2009-11-20 Published:2009-11-20
Supported by:
This work was supported by the NSF/NIH initiative on Mathematical Biology through R01GM75309 and R01GM67247 from the National Institute of General Medical Sciences, and by NIH P50GM76516 and NSF DMS0917492.

摘要/Abstract

摘要：

Scaffold proteins play an important role in the promotion of signal transmission and specificity during cell signaling. In cells, signaling proteins that make up a pathway are often physically orgnaized into complexes by scaffold proteins[1]. Previous work [2] has shown that
spatial localization of scaffold can enhance signaling locally while simultaneously suppressing signaling at a distance, and the membrane confinement of scaffold proteins may result in a precipitous spatial gradient of the active product protein, high close to the membrane and low within the cell. However, cell-fate decisions critically depend on the temporal pattern of product protein close to the nucleus. In this paper, when phosphorylation signals cannot be transfered by diffusion only, two mechanisms have been proposed for long-range signaling within cells: multiple locations of scaffold proteins and dynamical movement of scaffold proteins. Thus, here we have unveiled how the spatial propagation of the phosphorylated product protein within a cell depends on the spatially and temporal localized scaffold proteins. A class of novel and fast numerical methods for solving stiff reaction diffusion equations with complex domains is briefly introduced.

关键词: scaffold proteins, signal pathway, reaction-diffusion equations

Abstract:

Key words: scaffold proteins, signal pathway, reaction-diffusion equations

中图分类号:

92B99

Xinfeng Liu, Qing Nie. SPATIALLY-LOCALIZED SCAFFOLD PROTEINS MAY FACILITATE TO TRANSMIT LONG-RANGE SIGNALS[J]. 数学物理学报(英文版), 2009, 29(6): 1657-1669.

Xinfeng Liu, Qing Nie. SPATIALLY-LOCALIZED SCAFFOLD PROTEINS MAY FACILITATE TO TRANSMIT LONG-RANGE SIGNALS[J]. Acta mathematica scientia,Series B, 2009, 29(6): 1657-1669.

参考文献

[1] Pawson T, Scott J D. Signaling through scaffold, anchoring, and adaptor proteins. Science, 1997, 278: 2075--2080

[2] Bardwell L, Liu X F, Moore R D, Nie Q. Spatially-localized scaffold proteins may simultaneously boost and suppress signaling. Preprint, 2009

[3] Burack W R, Shaw A S. Signal transduction: hanging on a scaffold. Curr Opin Cell Biol, 2000, 12: 211--216

[4] Bhattacharyya R P, Remenyi A, Yeh B J, Lim W A. Domians, motifs, and scaffolds: The role of modular interactions in evolution and wiring of cell signaling circuits. Annu Rev Biochem, 2006, 75: 655--680

[5] Whitmarsh A J, Davis R J. Structural organization of MAP-kinase signaling modules by scaffold proteins in yeast and mammals. Trends Biochem Sci, 1998, 23: 481--485

[6] Morrison D K, Davis R J. Regulation of MAP Kinase signaling modules by scaffold proteins in mammals. Annu Rev Cell Dev Biol, 2003, 19: 91--118

[7] Wong W, Scott J D. AKAP signalling complexes: focal points in space and time. Nat Rev Mol Cell Biol, 2004, 5: 959--970

[8] Park S H, Zarrinpar A, Lim W A. Rewiring MAP kinase pathways using alternative scaffold assembly mechanisms. Science, 2003, 299: 1061--1064

[9] Harris K, Lamson R E, Nelson B, Hughes T R, Marton M J, Roberts C J, Boone C, Pryciak P M. Role of scaffolds in MAP kinase pathway specificity revealed by custom design of pathway-dedicated signaling proteins. Curr Biol, 2001, 11: 1815--1824

[10] Dickens M, Rogers J S, Cavanagh J, Raitano A, Xia Z, Halpern J R, Greenberg M E, Sawyers C L, Davis R J. A cytoplasmic inhibitor of the JNK signal transduction pathway. Science, 1997, 277: 693--696

[11] Cohen L, Henzel W J, Baeuerle P A. IKAP is a scaffold protein of the IkB kinase complex. Nature, 1998, 395: 292--296

[12] Kortum R L, Lewis R E. The molecular scaffold KSR1 regulates the proliferative and oncogenic potential of cells. Mol Cell Biol, 2004, 24: 4407--4416

[13] Kholodenko B N. Negative feedback and ultrasensitivity can bring about oscillations in the motigen-activated protein kinase cascades. Eur J Biochem, 2000, 267: 1583--1588

[14] Maly I V, Wiley H S, Lauffenburger D A. Self-orgnization of polarized cell signaling via autocrine circuits: computational model and analysis. Biophys J, 2004, 86: 10--22

[15] Howe C L, Mobley W C. Signaling endosome hypothesis: A cellular mechanism for long distance communication. Journal of Neurobiology, 2004, 58(2): 207--216

[16] Kholodenko B N. MAP kinase cascade signaling and endocytic trafficking: a marriage of convenience? Trends in Cell Biology, 2002, 12(4): 173--177

[17] Miaczynska M, Pelkmans L, Zerial M. Not just a sink: endosomes in control of signal transduction. Current Opinion in Cell Biology, 2004, 16(4): 400--406

[18] Perlson E, Hanz S, Ben-Yaakov K, Segal-Ruder Y, Seger R, Fainzilber M. Vimentin-dependent spatial translocation of an activated MAP kinase in injured nerve. Neuron, 2005, 45(5): 715--726

[19] Kholodenko B N. Four-dimensional organization of protein kinase signaling cascades: the roles of diffusion, endocytosis and molecular motors. Journal of Experimental Biology, 2003, 206(12): 2073--2082

[20] Slepchenko B M, Terasaki M. Cyclin aggregation and robustness of bio-switching. Molecular Biology of the Cell, 2003, 14(11): 4695--4706

[21] Zhang Y -T, Nie Q, Zhao R. Efficient semi-implicit schemes for stiff systems. Journal of Computational Physics, 2006, 214: 521--537

[22] Zhang Y T, Nie Q, Wan F Y M, Liu X F. Integration factor methods for high spatial dimensions. Journal of Computational Physics, 2008, 277: 5238--5255

[23] Elion E A. The Ste5p scaffold, 2001

[24] van Drogen F, Peter M. MAP kinase dynamics in yeast. Biol Cell, 2001, 93(1/2): 63--70

[25] van Drogen F, Peter M. Spa2p functions as a scaffold-like protein to recruit the Mpk1p MAP kinase module to sites of polarized growth. Current Biology, 2002, 12(19): 1698--1703

[26] Brent Roger. Physiology and genetic regulation of cellular signal transmission. ICSB talk, 2007

[27] Bashor C J, Helman N C, Yan S, Lim W A. Using engineered scaffold interactions to reshape MAP kinase pathway signaling dynamics. Science, 2008, 319(5869): 1539--1543

SPATIALLY-LOCALIZED SCAFFOLD PROTEINS MAY FACILITATE TO TRANSMIT LONG-RANGE SIGNALS

SPATIALLY-LOCALIZED SCAFFOLD PROTEINS MAY FACILITATE TO TRANSMIT LONG-RANGE SIGNALS

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