Chinese Journal of Magnetic Resonance

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An NMR Study of Phosphoramidon and Its β -Anomer

SUN Qi*,YANG Qing-kun,GONG Shan-shan,MA Cha   

  1. Jiangxi Key Laboratory of Organic Chemistry, Jiangxi Science and Technology Normal University, Nanchang 330013, China
  • Received:2013-09-18 Revised:2014-07-17 Online:2014-09-05 Published:2014-09-05
  • About author:*Corresponding author:SUN Qi, Tel: 13576930359,E-mail: sunqi96@tsinghua.org.cn.
  • Supported by:

    国家自然科学基金资助项目(21262014);江西省自然科学基金资助项目(20114BAB203008);人事部2011 年度留学人员科技活动项目择优资助项目;2012 年度教育部科学技术研究重点资助项目(2012092).

Abstract:

Phosphoramidon is a naturally occurring glycopeptide isolated from the culture of Streptomyces tanashiensis. As an inhibitor of metalloproteases, phosphoramidon has many important applications in biological and medicinal research. On the basis of one-dimensional (i.e., 1H, 13C, and 31P) and two-dimensional (i.e., 1H-1H COSY, HSQC, and NOESY) NMR spectral data, the NMR signals for phosphoramidon and its β -anomer were assigned. The anomeric configurations of the two isomers were determined.

Key words: phosphoramidon, structural elucidation, one-dimensional NMR, twodimensional NMR, anomeric configuration

CLC Number: