Chinese Journal of Magnetic Resonance

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Triterpenoid Saponins and Flavonoids from Clinopodium Linn.: Chemical Component Analyses and NMR Spectral Features

WANG Sheng-nan1, YU Shi-chun1,3*, XU Xu-dong2, SHE Shou-jun3, FAN Shi-hu3   

  1. 1. Anhui University of Traditional Chinese Medicine, Hefei 230031, China; 
    2. Institute of Medicinal Plant Development, Beijing Union Medical College, 
    Chinese Academy of Medical Sciences, Beijing 100193, China;
    3. Anhui Science Institute for Drug Research Co. Ltd., Hefei 230088, China
  • Received:2012-08-30 Revised:2013-04-08 Online:2013-09-05 Published:2013-09-05
  • About author:*Corresponding author: Yu Shi-chun, Tel: 13956081725, E-mail:shichunyu@hotmail.com.
  • Supported by:

    国家自然科学基金资助项目(81173511);“十一五”“重大新药创制”国家科技重大专项——综合性新药研究开发技术大平台资助(2009ZX093012003).

Abstract:

This paper reviews domestic and international research progresses in studying the structures and NMR spectral features of triterpenoid saponins and flavonoids in Labiatae Clinopodium. So far, 42 saponins and 23 flavonoids have been isolated and identified. Base on the NMR data of alkene carbon and carbonyl carbon, the basic structures of triterpenoid saponins can be speculated. According to the chemical shifts of oxygenated carbon and the adjacent carbon, the hydroxyl substitution position can be determined. The type of sugar and connection location can be identified by the carbon spectral date of triterpenoid saponions. Meanwhile, the characteristic spectral features of flavonoids are summarized. NMR spectral characterization of triterpenoid saponins and flavonoids of the Clinopodium will facilitate further identification of new compounds from Clinopodium Linn.

Key words: Clinopodium, category, saponins, flavonoid, spectral features

CLC Number: