Design of a Miniaturized NMR Spectrometer Console Based on FPGA

Abstract

Abstract:

To meet the functionality requirements and the trend of instrument miniaturization, a miniaturized NMR spectrometer console system based on fieldprogrammable gate array (FPGA) and advanced RISC machines (ARM) is proposed. This digital console has the advantages of extremely high processing speed, accurate control, short development cycle and low costs. In this paper, we introduce the functions of FPGA in the system, including data receiving, parameter configuration, pulse emission and data sampling modules. The ARM embedded module achieves the function of Ethernet communication between the console and host computer, such that the internal operation of the console will not be disturbed by the network status.

Key words: NMR spectrometer, console, FPGA, ARM

CLC Number:

O482.53

XIAO Ying, ZHENG Zhen-Yao, CAI Shu-Hui, CHEN Zhong. Design of a Miniaturized NMR Spectrometer Console Based on FPGA[J]. Chinese Journal of Magnetic Resonance, 2012, 29(3): 346-353.

References

[1] Bayer E, Traxler M. A high-resolution (<10 ps RMS) 48-channel time-to-digital converter (TDC) implemented in a field programmable gate array (FPGA)[J]. Nuclear Science, 2011, 58(4): 1 547-1 522.

[2] Fernandes A M, Pereira R C, Sousa J, et al. HDL based FPGA interface library for data acquisition and multipurpose real time algorithms[J]. Nuclear Science, 2011, 58(4): 1 526-1 530.

[3] Akiyama M, Sakugawa T, Hosseini S H R. High-performance pulsed-power generator controlled by FPGA[J]. Plasma Science, 2010, 38(10): 2 588-2 592.

[4] Chappell L A, Tittel E. TCP/IP协议原理与应用[M]. Beijing(北京)：Tsinghua University Press(清华大学出版社)，2009.

[5] Palnitkar S. Verilog HDL数字设计与综合[M]. Beijing(北京)：Publish House of Electronics Industry(电子工业出版社)，2004.

[6] Tian Yun(田耘), Xu Wen-bo(徐文波), Hu Bin(胡彬), et al．Xilinx ISE Design Suite 10.x FPGA开发指南. 逻辑设计篇[M]. Beijing(北京)：Posts & Telecom Press(人民邮电出版社)，2008.

[7] Tian Yun(田耘), Hu Bin(胡彬), Xu Wen-bo(徐文波), et al．Xilinx ISE Design Suite 10.x FPGA开发指南. DSP、嵌入式与高速传输篇[M]. Beijing(北京)：Posts & Telecom Press(人民邮电出版社)，2008.

[8] Donahoo M J, Calvert K L. TCP/IP Sockets编程：C语言实现[M]. Beijing(北京)：Tsinghua University Press(清华大学出版社)，2009.

[9] Hu Peng(胡鹏), Yang Liang(杨亮), Hu Shao-bin(胡少斌), et al. Design and implementation of NMR receiver(核磁共振波谱仪接收机的设计与实现)[J]. Chinese J Magn Reson(波谱学杂志), 2011, 28(1): 42-49.

[10] Xie Qing-ming(谢庆明), Xiao Li-zhi(肖立志), Zhang Xiao-ling(张晓玲), et al. Design and implementation of An FPGA-Based pulse programmer for low field NMR spectrometer(基于FPGA的低场核磁共振波谱仪脉冲编程器设计与实现)[J]. Chinese J Magn Reson(波谱学杂志), 2011, 28(3): 317-325.

[11] Chen Nan(陈楠), Chen Jie-hua(陈杰华), Hu Peng(胡鹏), et al. A digital transmitter for NMR based on FPGA(核磁共振波谱仪接收机的设计与实现)[J]. Chinese J Magn Reson(波谱学杂志), 2008, 25(2): 243-249.

[1]	HUANG Zhao-hui, ZHANG Zhi, CHEN Li, CHEN Jun-fei, ZHANG Zhen, CHEN Fang, LIU Chao-yang. A Time-Division Multiplexing Design for Gradient Preemphasis Module in Magnetic Resonance Imaging Scanner [J]. Chinese Journal of Magnetic Resonance, 2018, 35(4): 465-474.
[2]	CUI Yan, XIAO Liang. High Accuracy Generation and Test of B₀ Signals on Magnetic Resonance Imaging Spectrometer [J]. Chinese Journal of Magnetic Resonance, 2018, 35(2): 170-177.
[3]	HU Jin-jie, YAO Jun-jiang, XU Jun-Cheng, LIU Jun, WANG Zi, JIANG Yu. A Magnetic Resonance Imaging Receiver Design Based on NI PXIe-7966R [J]. Chinese Journal of Magnetic Resonance, 2017, 34(4): 489-497.
[4]	HE Gang, WANG Wei-min. A Multi-Channel Radiofrequency Transmitter for High-Field MRI [J]. Chinese Journal of Magnetic Resonance, 2017, 34(3): 338-346.
[5]	ZHOU Qi, HUANG Chong-yang, GAO Shan, WANG Hui-juan, FENG Ji-wen, LIU Chao-yang, ZHANG Jin-zhi, ZOU Qi-chao. Structure Elucidation of Taxol Based on Two-Dimensional NMR Spectra Collected on a 500 MHz NMR Spectrometer Built In-House [J]. Chinese Journal of Magnetic Resonance, 2017, 34(1): 52-60.
[6]	LI Yu-wei, XIAO Liang. A Radio Frequency Pulse Generator for Magnetic Resonance Imaging Based on FPGA and DDS [J]. Chinese Journal of Magnetic Resonance, 2016, 33(4): 590-596.
[7]	WANG Li-min, QIU Ru-chen, HUANG Shao-hua. Quantitative Analysis of Active Ingredients in Compound Acetylsalicylic Acid Tablets by DOSY [J]. Chinese Journal of Magnetic Resonance, 2016, 33(3): 415-421.
[8]	HE Yu-gui1,2，FENG Ji-wen1，ZHANG Zhi1,3，WANG Chao1,3，NI Sheng1，HU Shao-bin1，WANG Dong1，CHEN Fang1，LIU Mai-li1，LIU Chao-yang1. Development of Pulsed Dynamic Nuclear Polarization for Enhancing NMR and MRI [J]. Chinese Journal of Magnetic Resonance, 2015, 32(2): 393-398.
[9]	MAO Wen-ping，LI Yun-yan，LIU Zao，BAO Qing-jia，LIU Chao-yang*. A Transmitter Capable of Fast Modulation for NMR Spectrometer-Design and Implementation [J]. Chinese Journal of Magnetic Resonance, 2013, 30(1): 12-20.
[10]	ZHANG Zhi, MAO Wen-Ping, LIU Chao-Yang. Progress in the Development of Pulse Programmer for Nuclear Magnetic Resonance [J]. Chinese Journal of Magnetic Resonance, 2012, 29(3): 339-345.
[11]	YU Hui-Jun, XIAO Li-Zhi, V. Anferov, S. Anferova, ZHU Wan-Li, LIU Hua-Bing, GUO Bao-Xin. Design of An FPGA-Based Control Logic in NMR Logging Tool [J]. Chinese Journal of Magnetic Resonance, 2012, 29(2): 201-208.
[12]	SHANG Yun, ZHOU Juan, LEI Dou, XU Jun-Cheng, JIANG Yu. Software System Design in an Integrated NMR Spectrometer Console [J]. Chinese Journal of Magnetic Resonance, 2012, 29(1): 68-77.
[13]	YANG Liang, BAO Qiang-Jia, MAO Wen-Ping, LIU Chao-Yang. System Performance Evaluation of a Self-Developed NMR Spectrometer [J]. Chinese Journal of Magnetic Resonance, 2012, 29(1): 78-85.
[14]	XIE Qiang-Ming, XIAO Li-Zhi, ZHANG Xiao-Ling, LI Xiao-Nan. Design and Implementation of An FPGA-Based Pulse Programmer for Low Field NMR Spectrometer [J]. Chinese Journal of Magnetic Resonance, 2011, 28(3): 317-325.
[15]	ZHANG Ye, LIU Xiao-Peng, ZHANG You-Jie. Studies of NMR Quantitative Analysis for Water-Soluble Vitamins [J]. Chinese Journal of Magnetic Resonance, 2011, 28(3): 357-365.