Syntheses and Spin Trapping-ESR Studies of Novel Saturated Alkyl Spin-traps

Chinese Journal of Magnetic Resonance ›› 2009, Vol. 26 ›› Issue (2): 188-196.

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Syntheses and Spin Trapping-ESR Studies of Novel Saturated Alkyl Spin-traps

ZHAO Ji-shou¹*; CHU Yu-jie^1,2; DU Li-Bo²; HAN Lu²; YAO Tong-wei³; 
HE Chao¹; WANG Wei-jun¹; TIAN Qiu²; JIA Hong-ying²; LIU Yang²*

(1.State Key Laboratory of Ethnic Medicine, College of Chemistry and Biotechnology, Yunnan Nationalities University, Kunming 650031, China;
2.State Key Laboratory for Structural Chemistry of Unstable and Stable Species, Institute of Chemistry, Chinese Academy of Science, Beijing 100190, China; 3.Faculty of Sciences, Beijing University of Chemical Technology, Beijing 100029, China)

Received:2008-11-24 Revised:2008-12-27 Online:2009-06-05 Published:2009-12-05
Contact: ZHAO Ji-Shou; LIU Yang

Abstract

Abstract: Two new saturated alkyl linear nitrone spin-traps [N-(Ethylidene)-t- butylamine N-oxide] (EBN) and (N-(Ethylidene)-1-diethoxyphosphoryl-1- methylethylamine -Oxide) (EPN) were synthesized. Characterization of the structures of these spin traps were carried out using NMR, MS, IR, UV and other means. The two compounds were shown to be able to trap hydroxyl radicals produced in the Fenton reaction and carbon-, oxygen- or sulfur- entered radicals.

Key words: electron-spin resonance (ESR), nitrone spin trap, EBN, EPN, radicals

CLC Number:

O482.53

ZHAO Ji-shou¹*; CHU Yu-jie^1,2; DU Li-Bo²; HAN Lu²; YAO Tong-wei³; 
HE Chao¹; WANG Wei-jun¹; TIAN Qiu²; JIA Hong-ying²; LIU Yang²*. Syntheses and Spin Trapping-ESR Studies of Novel Saturated Alkyl Spin-traps[J]. Chinese Journal of Magnetic Resonance, 2009, 26(2): 188-196.

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Syntheses and Spin Trapping-ESR Studies of Novel Saturated Alkyl Spin-traps

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