Influence of Hydroxylamine Derivatives and Phenolic Compounds on the Fluidity of Erythrocyte Membrane

Abstract

Abstract:

The fluidity of erythrocyte membrane in the presence of xenobiotics, such as hydroxylamine derivatives and phenolic compounds was studied by ESR in combination with spin labeling technique. The results indicated that the fluidity inside the membrane decreased evidently in the presence hydroxylamine derivatives and cumyl hydroperoxide, as results of oxidative stress and cross-link of the membrane lipids. In contrast, the mobility of the lipids on the surface of the membrane was increased, mainly due to the direct membrane effect from the small organic molecules. Accordingly, both hydroxylamine derivatives and phenolic compounds enhanced the fluidity of the surface of erythrocyte membrane.

Key words: ESR, spin labeling, fluidity of membrane, erythrocyte, pro-oxidative damage

CLC Number:

O482.53

SONG Yu-Guang, SUN Jian, Nohl Hans, LIU Yang. Influence of Hydroxylamine Derivatives and Phenolic Compounds on the Fluidity of Erythrocyte Membrane[J]. Chinese Journal of Magnetic Resonance, 2005, 22(4): 349-356.

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