波谱学杂志 ›› 2007, Vol. 24 ›› Issue (4): 480-486.

• 祝贺邬学文先生八十华诞(专辑) • 上一篇    下一篇

胰腺癌和慢性胰腺炎的胰液核磁共振1H谱分析

方芳1, 何新红2, 陆建平2, 陈群1, 余亦华1*   

  1. 1.上海市功能磁共振成像重点实验室,华东师范大学 物理系,上海 200062;
    2.第二军医大学长海医院放射科,上海 200433
  • 收稿日期:2007-08-28 出版日期:2007-12-05 发布日期:2007-12-05
  • 作者简介:方芳(1977-),女,湖北武汉人,博士研究生,无线电物理专业.*通讯联系人:余亦华,电话:021-62233281,E-mail:yhyu@phy.ecnu.edu.cn.
  • 基金资助:

    国家自然科学基金资助项目(30470514).

NMR Spectra of Pancreatic Fluids Can Be Used to Differentiate Chronic Pancreatitis from Pancreatic Cancer

FANG Fang1, HE Xin-hong2, LU Jian-ping2, CHEN Qun1, YU Yi-hua1*   

  1. 1.Shanghai Key Laboratory of Functional Magnetic Resonance Imaging, Department of  Physics, East China Normal University, 200062 Shanghai; 
    2.Department of Radiology, Changhai Hospital, The Second Military Medical University, 200433 Shanghai
  • Received:2007-08-28 Online:2007-12-05 Published:2007-12-05
  • About author:*Corresponding author:Yu Yi-hua,Tel: 021-62233281,E-mail:yhyu@phy.ecnu.edu.cn.
  • Supported by:

    国家自然科学基金资助项目(30470514).

摘要:

运用核磁共振波谱技术对临床慢性胰腺炎和胰腺癌患者的胰液样品进行体外波谱学分析,观察和鉴别胰腺癌和慢性胰腺炎的特征代谢物变化,从而为胰腺癌以及相关胰腺疾病的病理研究提供基础数据和实验方法. 本文利用胰液样品在室温下能长时间稳定的特性,对其进行了质子的1D、TOCSY和J-resolved等多种NMR实验,并对其主要特征峰进行了指认. 实验结果显示在δ 1.19的三重峰是这两种病变在胰液中的主要区别:只在慢性胰腺炎图谱中观察到,而在胰腺癌图谱中未见. D实验结果表明此特征峰为乙氧基中的甲基峰,而乙氧基可能与胰腺中乙醇的代谢有关

关键词: 核磁共振波谱, 胰液, 胰腺癌, 慢性胰腺炎, 乙氧基

Abstract:

We applied nuclear magnetic resonance spectroscopy(NMR)to study pancreatic juice (PJ) taken from patients with chronic pancreatitis (CP) and pancreatic cancer. The aim of the study is to assign the main resonances in the 1H NMR spectra of PJ and to discover the characteristic metabolites the changes of which can be used to differentiate CP from pancreatic cancer. 1D proton spectroscopy, 2D TOCSY and J-resolved spectra (JRES) were performed to assign the main resonances. We found a triplet at δ1.19 that only appeared in the spectra of PJ from the CP patients, but not in the spectra of PJ from the pancreatic cancer patients. The triplet was assigned to be the resonance of ethoxyl, which might be associated with the metabolism of alcohol in pancreas.

Key words: nuclear magnetic resonance spectroscopy, pancreatic juice, chronic pancreatitis, pancreatic cancer, ethoxyl

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