磷氨米酮及其β-端位异构体的NMR 研究

波谱学杂志

磷氨米酮及其β-端位异构体的NMR 研究

孙麒*，杨庆昆，龚珊珊，马茶

江西科技师范大学有机功能分子研究所，江西南昌 330013

收稿日期:2013-09-18 修回日期:2014-07-17 出版日期:2014-09-05 发布日期:2014-09-05
作者简介:孙麒(1978-)，男，北京人，博士，副教授，有机化学专业．电话：13576930359，E-mail：sunqi96@tsinghua.org.cn. *通讯联系人．
基金资助:
国家自然科学基金资助项目(21262014)；江西省自然科学基金资助项目(20114BAB203008)；人事部2011 年度留学人员科技活动项目择优资助项目；2012 年度教育部科学技术研究重点资助项目(2012092)．

An NMR Study of Phosphoramidon and Its β -Anomer

SUN Qi*，YANG Qing-kun，GONG Shan-shan，MA Cha

Jiangxi Key Laboratory of Organic Chemistry, Jiangxi Science and Technology Normal University, Nanchang 330013, China

Received:2013-09-18 Revised:2014-07-17 Online:2014-09-05 Published:2014-09-05
About author:*Corresponding author：SUN Qi, Tel: 13576930359，E-mail: sunqi96@tsinghua.org.cn.
Supported by:
国家自然科学基金资助项目(21262014)；江西省自然科学基金资助项目(20114BAB203008)；人事部2011 年度留学人员科技活动项目择优资助项目；2012 年度教育部科学技术研究重点资助项目(2012092)．

摘要/Abstract

摘要：

磷氨米酮是从链霉菌培养液中分离得到的一种天然磷酰糖肽．作为多种金属蛋白酶的抑制剂，磷氨米酮在生物和医学领域有着广泛的应用．该研究通过对化学合成磷氨米酮及其β-端位异构体的1D NMR 波谱(¹H，¹³C 和31P NMR)和2D NMR 波谱(¹H-¹H COSY，HSQC 和NOESY)的解析，对其NMR 信号进行了全归属，并确认了磷氨米酮及其β-端位异构体的端位构型．

关键词: 磷氨米酮(Phosphoramidon), 结构确认, 1D NMR, 2D NMR, 端位构型

Abstract:

Phosphoramidon is a naturally occurring glycopeptide isolated from the culture of Streptomyces tanashiensis. As an inhibitor of metalloproteases, phosphoramidon has many important applications in biological and medicinal research. On the basis of one-dimensional (i.e., ¹H, ¹³C, and ³¹P) and two-dimensional (i.e., ¹H-¹H COSY, HSQC, and NOESY) NMR spectral data, the NMR signals for phosphoramidon and its β -anomer were assigned. The anomeric configurations of the two isomers were determined.

Key words: phosphoramidon, structural elucidation, one-dimensional NMR, twodimensional NMR, anomeric configuration

中图分类号:

O482.53

孙麒*，杨庆昆，龚珊珊，马茶. 磷氨米酮及其β-端位异构体的NMR 研究[J]. 波谱学杂志.

SUN Qi*，YANG Qing-kun，GONG Shan-shan，MA Cha. An NMR Study of Phosphoramidon and Its β -Anomer[J]. Chinese Journal of Magnetic Resonance.

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