超极化129Xe MR用于COPD急性加重的肺功能研究

doi:10.11938/cjmr20243106

波谱学杂志 ›› 2024, Vol. 41 ›› Issue (4): 363-372.doi: 10.11938/cjmr20243106

超极化¹²⁹Xe MR用于COPD急性加重的肺功能研究

李连杰¹^,⁴^,^#, 郑瑜²^,³^,^#, 谢树光⁴^,⁶, 张鸣², 李红闯²^,⁵, 刘小玲²^,⁵, 赵修超²^,⁵, 韩叶清²^,⁵, 李海东²^,⁵, 范丽⁴, 萧毅⁴, 刘士远⁴^,^§(), 周欣²^,⁵^,^*()

1.上海理工大学，上海 200093
2.中国科学院精密测量科学与技术创新研究院，波谱与原子分子物理国家重点实验室，武汉磁共振中心，湖北武汉 430071
3.华中科技大学，湖北武汉 430074
4.海军军医大学第二附属医院放射诊断科，上海 200003
5.中国科学院大学，北京 100049
6.徐州医科大学医学影像学院，江苏徐州 221000

收稿日期:2024-03-28 出版日期:2024-12-05 在线发表日期:2024-04-13
通讯作者: * Tel: 027-87198631, E-mail: xinzhou@wipm.ac.cn;§ Tel: 021-81886012, E-mail: cjr.liushiuyuan@vip.163.com.
作者简介:^#共同第一作者
基金资助:
国家自然科学基金项目(81930049);国家自然科学基金项目(82127802);国家自然科学基金项目(21921004);国家自然科学基金项目(82372150);国家自然科学基金项目(82202119);国家重点研发计划(2018YFA0704000);国家重点研发计划(2022-YFC2410000);湖北省科技重大专项(2021ACA013);湖北省科技重大专项(2023BAA021);中国科学院重点项目(ZDBS-LY-JSC004);中国科学院重点项目(XDB0540000);中国科学院青年促进会专项(2020330);中国科学院青年促进会专项(2021330)

Assessment of Pulmonary Function Changes of AECOPD with Hyperpolarized ¹²⁹Xe MR

LI Lianjie¹^,⁴^,^#, ZHENG Yu²^,³^,^#, XIE Shuguang⁴^,⁶, ZHANG Ming², LI Hongchuang²^,⁵, LIU Xiaoling²^,⁵, ZHAO Xiuchao²^,⁵, HAN Yeqing²^,⁵, LI Haidong²^,⁵, FAN Li⁴, XIAO Yi⁴, LIU Shiyuan⁴^,^§(), ZHOU Xin²^,⁵^,^*()

1. University of Shanghai for Science and Technology, Shanghai 200093, China
2. State Key Laboratory of Spectroscopy and Atomic and Molecular Physics, Wuhan Center for Magnetic Resonance, Innovation Academy for Precision Measurement Science and Technology, Wuhan 430071, China
3. Huazhong University of Science and Technology, Wuhan 430074, China
4. Department of Radiology, Second Affiliated Hospital of Naval Medical University, Shanghai 200003, China
5. University of Chinese Academy of Sciences, Beijing 100049, China
6. School of Medical Imaging, Xuzhou Medical University, Xuzhou 221000, China

Received:2024-03-28 Published:2024-12-05 Online:2024-04-13
Contact: * Tel: 027-87198631, E-mail: xinzhou@wipm.ac.cn;§ Tel: 021-81886012, E-mail: cjr.liushiuyuan@vip.163.com.

摘要/Abstract

摘要：

慢性阻塞性肺疾病（COPD）急性加重（AECOPD）是COPD自然病程中的重要不良事件，本研究利用超极化¹²⁹Xe MR技术探究了AECOPD疾病模型的肺泡微结构和气血交换功能变化．结果表明，相比于肺气肿组，急性加重组的肺部微结构变化不大，但气血交换功能显著下降．这些测量结果与组织学以及肺功能检查结果具有较好的相关性，证明了超极化¹²⁹Xe MR对AECOPD检测的可行性与灵敏性．

关键词: 超极化¹²⁹Xe MR, 扩散加权成像, 化学位移饱和恢复, COPD, 肺气肿, 急性加重

Abstract:

The acute exacerbation of chronic obstructive pulmonary disease (AECOPD) constitutes a significant adverse event in the trajectory of COPD. In this study, we utilized hyperpolarized ¹²⁹Xe magnetic resonance (MR) to explore the alterations in alveolar microstructure and pulmonary gas exchange function in an AECOPD disease model. Our findings revealed that, in comparison to the emphysema group, the microstructure remained relatively unchanged in the acute exacerbation group, while gas exchange function exhibited a decrease. Notably, these observed changes correlated well with histological findings and pulmonary function assessments, indicating the feasibility and sensitivity of hyperpolarized ¹²⁹Xe MR in detecting AECOPD.

Key words: hyperpolarized ¹²⁹Xe MR, DWI, CSSR, COPD, emphysema, acute exacerbation

中图分类号:

O482.53

李连杰, 郑瑜, 谢树光, 张鸣, 李红闯, 刘小玲, 赵修超, 韩叶清, 李海东, 范丽, 萧毅, 刘士远, 周欣. 超极化¹²⁹Xe MR用于COPD急性加重的肺功能研究[J]. 波谱学杂志, 2024, 41(4): 363-372.

LI Lianjie, ZHENG Yu, XIE Shuguang, ZHANG Ming, LI Hongchuang, LIU Xiaoling, ZHAO Xiuchao, HAN Yeqing, LI Haidong, FAN Li, XIAO Yi, LIU Shiyuan, ZHOU Xin. Assessment of Pulmonary Function Changes of AECOPD with Hyperpolarized ¹²⁹Xe MR[J]. Chinese Journal of Magnetic Resonance, 2024, 41(4): 363-372.

图/表 9

图1

表1

图2

图3

表2

图4

图5

图6

图7

参考文献 32

[1]	SORIANO J B, ABAJOBIR A A, ABATE K H, et al. Global, regional, and national deaths, prevalence, disability-adjusted life years, and years lived with disability for chronic obstructive pulmonary disease and asthma, 1990-2015: a systematic analysis for the global burden of disease study 2015[J]. Lancet Respir Med, 2017, 5(9): 691-706. doi: 10.1016/S2213-2600(17)30293-X pmid: 28822787
[2]	DIAZ-GUZMAN E, MANNINO D M. Epidemiology and prevalence of chronic obstructive pulmonary disease[J]. Clin Chest Med, 2014, 35(1): 7-16.
[3]	MARCHIONI A, CASTANIERE I, TONELLI R, et al. Ultrasound-assessed diaphragmatic impairment is a predictor of outcomes in patients with acute exacerbation of chronic obstructive pulmonary disease undergoing noninvasive ventilation[J]. Crit Care, 2018, 22(1): 109.
[4]	RANGELOV B A, YOUNG A L, JACOB J, et al. Thoracic imaging at exacerbation of chronic obstructive pulmonary disease: a systematic review[J]. Int J Chron Obstruct Pulmon Dis, 2020, 15: 1751-1787.
[5]	WEI S S, LU R, ZHANG Z P, et al. MRI-assessed diaphragmatic function can predict frequent acute exacerbation of COPD: a prospective observational study based on telehealth-based monitoring system[J]. BMC Pulm Med, 2022, 22(1): 438. doi: 10.1186/s12890-022-02254-x pmid: 36424599
[6]	LI H D, ZHANG Z Y, HAN Y Q, et al. Hyperpolarized gas magnetic resonance imaging of the lung[J]. Chinese J Magn Reson, 2014, 31(3): 307-320.
	李海东, 张智颖, 韩叶清, 等. 超极化气体肺部磁共振成像[J]. 波谱学杂志, 2014, 31(3): 307-320.
[7]	ZHANG M, LI H D, LI H C, et al. Quantitative evaluation of lung injury caused by PM_2.5 using hyperpolarized gas magnetic resonance[J]. Magn Reson Med, 2020, 84(2): 569-578.
[8]	LI H D, ZHANG Z Y, ZHAO X C, et al. Quantitative evaluation of pulmonary gas-exchange function using hyperpolarized ¹²⁹Xe CEST MRS and MRI[J]. NMR Biomed, 2018, 31(9): e3961.
[9]	GUAN S, TUSTISON N, QING K, et al. 3D Single-breath chemical shift imaging hyperpolarized ¹²⁹Xe MRI of healthy, CF, IPF, and COPD subjects[J]. Tomography, 2022, 8(5): 2574-2587.
[10]	RANKINE L J, LU J L, WANG Z Y, et al. Quantifying regional radiation-induced lung injury in patients using hyperpolarized ¹²⁹Xe gas exchange magnetic resonance imaging[J]. Int J Radiat Oncol Biol Phys, 2024, 120(1): 216-228.
[11]	BOUDREAU M, XU X J, SANTYR G E. Measurement of ¹²⁹Xe gas apparent diffusion coefficient anisotropy in an elastase-instilled rat model of emphysema[J]. Magn Reson Med, 2013, 69(1): 211-220.
[12]	MATA J F, ALTES T A, CAI J, et al. Evaluation of emphysema severity and progression in a rabbit model: comparison of hyperpolarized ³He and ¹²⁹Xe diffusion MRI with lung morphometry[J]. J Appl Physiol (1985), 2007, 102(3): 1273-1280.
[13]	RUAN W W, ZHONG J P, WANG K, et al. Detection of the mild emphysema by quantification of lung respiratory airways with hyperpolarized xenon diffusion MRI[J]. J Magn Reson Imaging, 2017, 45(3): 879-888. doi: 10.1002/jmri.25408 pmid: 27472552
[14]	STEWART N J, CHAN H F, HUGHES P J C, et al. Comparison of ³He and ¹²⁹Xe MRI for evaluation of lung microstructure and ventilation at 1.5 T[J]. J Magn Reson Imaging, 2018, 48(3): 632-642.
[15]	KAUSHIK S S, CLEVELAND Z I, COFER G P, et al. Diffusion-weighted hyperpolarized ¹²⁹Xe MRI in healthy volunteers and subjects with chronic obstructive pulmonary disease[J]. Magn Reson Med, 2011, 65(4): 1154-1165.
[16]	SAKAI K, BILEK A M, OTEIZA E, et al. Temporal dynamics of hyperpolarized ¹²⁹Xe resonances in living rats[J]. J Magn Reson B, 1996, 111(3): 300-304.
[17]	CHANG Y V. MOXE: A model of gas exchange for hyperpolarized ¹²⁹Xe magnetic resonance of the lung[J]. Magn Reson Med, 2013, 69(3): 884-890.
[18]	KERN A L, GUTBERLET M, QING K, et al. Regional investigation of lung function and microstructure parameters by localized ¹²⁹Xe chemical shift saturation recovery and dissolved-phase imaging: A reproducibility study[J]. Magn Reson Med, 2019, 81(1): 13-24.
[19]	MUMMY D G, COLEMAN E M, WANG Z Y, et al. Regional gas exchange measured by ¹²⁹Xe magnetic resonance imaging before and after combination bronchodilators treatment in chronic obstructive pulmonary disease[J]. J Magn Reson Imaging, 2021, 54(3): 964-974.
[20]	KIRBY M, EDDY R L, PIKE D, et al. MRI ventilation abnormalities predict quality-of-life and lung function changes in mild-to-moderate COPD: longitudinal TINCan study[J]. Thorax, 2017, 72(5): 475-477. doi: 10.1136/thoraxjnl-2016-209770 pmid: 28258250
[21]	TAFTI S, GARRISON W J, MUGLER J P 3^rd, et al. Emphysema index based on hyperpolarized ³He or ¹²⁹Xe diffusion MRI: performance and comparison with quantitative CT and pulmonary function tests[J]. Radiology, 2020, 297(1): 201-210.
[22]	QING K, MUGLER J P 3^rd, ALTES T A, et al. Assessment of lung function in asthma and COPD using hyperpolarized ¹²⁹Xe chemical shift saturation recovery spectroscopy and dissolved-phase MRI[J]. NMR Biomed, 2014, 27(12): 1490-1501.
[23]	STEWART N J, HORN F C, NORQUAY G, et al. Reproducibility of quantitative indices of lung function and microstructure from ¹²⁹Xe chemical shift saturation recovery (CSSR) MR spectroscopy[J]. Magn Reson Med, 2017, 77(6): 2107-2113.
[24]	CHEN X M, ZHAO X C, SUN X P, et al. Study on the automatic accumulation-thawing device of hyperpolarized ¹²⁹Xe[J]. Chinese J Magn Reson, 2022, 39(3): 316-326.
	陈小明, 赵修超, 孙献平, 等. 超极化¹²⁹Xe自动收集-升华装置研究[J]. 波谱学杂志, 2022, 39(3): 316-326. doi: 10.11938/cjmr20222998
[25]	WOODS J C, CHOONG C K, YABLONSKIY D A, et al. Hyperpolarized ³He diffusion MRI and histology in pulmonary emphysema[J]. Magn Reson Med, 2006, 56(6): 1293-1300.
[26]	SOHRABI F, DIANAT M, BADAVI M, et al. Gallic acid suppresses inflammation and oxidative stress through modulating Nrf2-HO-1-NF-κB signaling pathways in elastase-induced emphysema in rats[J]. Environ Sci Pollut Res Int, 2021, 28(40): 56822-56834.
[27]	DE OLIVEIRA M V, ROCHA N N, SANTOS R S, et al. Endotoxin-induced emphysema exacerbation: a novel model of chronic obstructive pulmonary disease exacerbations causing cardiopulmonary impairment and diaphragm dysfunction[J]. Front Physiol, 2019, 10: 664. doi: 10.3389/fphys.2019.00664 pmid: 31191356
[28]	KOBAYASHI S, FUJINAWA R, OTA F, et al. A single dose of lipopolysaccharide into mice with emphysema mimics human chronic obstructive pulmonary disease exacerbation as assessed by micro-computed tomography[J]. Am J Respir Cell Mol Biol, 2013, 49(6): 971-977.
[29]	ZHANG M, LI H D, LI H C, et al. Dynamic evaluation of acute lung injury using hyperpolarized ¹²⁹Xe magnetic resonance[J]. NMR Biomed, 2024, 37(4): e5078.
[30]	TOLNAI J, SZABARI M V, ALBU G, et al. Functional and morphological assessment of early impairment of airway function in a rat model of emphysema[J]. J Appl Physiol (1985), 2012, 112(11): 1932-1939.
[31]	KIRBY M, PIKE D, COXSON H O, et al. Hyperpolarized ³He ventilation defects used to predict pulmonary exacerbations in mild to moderate chronic obstructive pulmonary disease[J]. Radiology, 2014, 273(3): 887-896.
[32]	ZINELLU A, MANGONI A A. The emerging clinical significance of the red cell distribution width as a biomarker in chronic obstructive pulmonary disease: a systematic review[J]. J Clin Med, 2022, 11(19): 5642.

参数	NS组	PPE组	AE组	P值^a	P值^b	P值^c
ADC/（cm²/s）	0.028±0.001	0.033±0.003	0.032±0.002	0.0014	0.3540	0.0112
L_m/μm	85.71±4.94	101.11±6.59	98.77±7.94	0.0009	0.5314	0.0044
SVR/cm^-1	508.50±1.44	411.09±26.86	435.62±37.89	0.0001	0.1739	0.0010

参数	NS组	PPE组	AE组	P值^a	P值^b	P值^c
T/ms	15.36±2.37	20.20±5.79	26.21±4.90	0.112	0.054	0.003
d/μm	7.06±1.22	8.04±1.13	9.21±0.88	0.095	0.055	0.002
Δ/d	0.149±0.038	0.180±0.033	0.122±0.018	0.129	0.009	0.193
HCT	0.335±0.051	0.298±0.014	0.189±0.030	0.102	0.001	0.001
SVR/cm^-1	219.36±38.64	187.56±19.87	181.78±35.12	0.119	0.767	0.082
η	0.511±0.057	0.470±0.016	0.326±0.047	0.132	0.001	0.001

超极化¹²⁹Xe MR用于COPD急性加重的肺功能研究

Assessment of Pulmonary Function Changes of AECOPD with Hyperpolarized ¹²⁹Xe MR

RichHTML

PDF

可视化

摘要/Abstract

引用本文

使用本文

图/表 9

参考文献 32

相关文章 3

编辑推荐

Metrics

本文评价

[1]	杨黎明, 王远军. 扩散张量图像去噪算法研究进展[J]. 波谱学杂志, 2024, 41(3): 341-361.
[2]	王崇武,黄曦,石磊,陈世桢,周欣. 组织蛋白酶B响应的超极化¹²⁹Xe MRI探针对肺癌细胞的超灵敏探测[J]. 波谱学杂志, 2021, 38(3): 336-344.
[3]	王前锋, 李建奇, 吴东梅, 王小楼, 贾杰, 张敏, 李鲠颖. 小动物高分辨扩散加权成像在临床MRI上的实现[J]. 波谱学杂志, 2012, 29(3): 372-378.