波谱学杂志 ›› 1984, Vol. 1 ›› Issue (5): 481-485.

• 研究论文 • 上一篇    下一篇

电子自旋共振波谱研究山莨菪碱对二棕榈酰磷脂酸脂质体流动性的影响

黄芬1, 陈建文1, 赵宝贞1, 王者福2   

  1. 1. 中国科学院生物物理研究所;
    2. 天津南开大学元素有机化学所
  • 收稿日期:1984-06-25 修回日期:1984-09-08 出版日期:1984-09-05 发布日期:2018-01-25

ESR STUDIES OF THE EFFECT OF ANISODAMINE ON THE FLUIDITY OF DIPALMITOYLPHOSPHATIDIC ACID LIPOSOMES

Hwang Fen1, Chen Jianwen1, Chao Baochung1, Wang Zhefu2   

  1. 1. Institute of Biophsics, Academia Sinica;
    2. Institute of Elemento-organic Chemistry, Nanki University
  • Received:1984-06-25 Revised:1984-09-08 Online:1984-09-05 Published:2018-01-25

摘要: 本文采用电子自旋共振波谱技术研究山莨菪碱对酸性磷脂二棕榈酰磷脂酸脂质体流动性的影响,实验结果表明,山莨菪碱能增加二棕榈酰磷脂酸脂质体的流动性,降低脂质体的相变温度10℃以上,同时出现分相现象。缓冲液的PH对自旋标记探针渗入二棕榈酰磷脂酸脂质体的电子自旋共振波谱图形有明显影响。

Abstract: The effect of anisodamine on the fluidity of dipalmitoylphosphatidic acid liposomes has been studied by ESR technique. Results indicate that anisodamine interacts strongly with dipalmitoylphosphatidic acid membranes. Anisodamine can increase the fluidity of dipalmitoylphatidic acid liposomes with a decrease in phase transition temperature for more than 10℃ and an exhibition of phase separation. The effect of pH on the dipalmitoylphosphatidic acid liposomes also has been discussed.