血卟啉衍生物(Photofrin Ⅱ)对DNA的光敏损伤——31P核磁共振波谱的研究

波谱学杂志 ›› 1989, Vol. 6 ›› Issue (4): 473-478.

血卟啉衍生物(Photofrin Ⅱ)对DNA的光敏损伤——³¹P核磁共振波谱的研究

陈凤英

中国科学院生物物理所

收稿日期:1988-07-07 修回日期:1988-12-20 出版日期:1989-12-05 发布日期:2018-01-22

THE EFFECT OF PHOTOFRIN Ⅱ ON THE PHOTOSENSITJZATION DAMAGE OF DNA ³¹P NMR INVESTIGATION

Chen Fengyin

Institute of Biophysics, Academia Sinica, Beijing 100080, China

Received:1988-07-07 Revised:1988-12-20 Online:1989-12-05 Published:2018-01-22

摘要/Abstract

摘要： 本文用³¹P核磁共振技术研究在光敏药物Photofrin Ⅱ作用下,DNA分子光敏损伤过程中的构象变化,损伤程度以及该药物与DNA分子可能的结合方式.

关键词: ¹³P核磁共振, 血卟啉衍生物, DNA光敏损伤

Abstract: The variation of conformation of DNA during its photosensitization damage rocess induced by the interaction of photofrin Ⅱ was studied by ³¹P NMR spectroscopy. The degree of damage and the possible mode of complexation are discussed.

Key words: ³¹P NMR, Photofrin Ⅱ, DNA photosensitization damage

陈凤英. 血卟啉衍生物(Photofrin Ⅱ)对DNA的光敏损伤——³¹P核磁共振波谱的研究[J]. 波谱学杂志, 1989, 6(4): 473-478.

Chen Fengyin. THE EFFECT OF PHOTOFRIN Ⅱ ON THE PHOTOSENSITJZATION DAMAGE OF DNA ³¹P NMR INVESTIGATION[J]. Chinese Journal of Magnetic Resonance, 1989, 6(4): 473-478.

血卟啉衍生物(Photofrin Ⅱ)对DNA的光敏损伤——³¹P核磁共振波谱的研究

THE EFFECT OF PHOTOFRIN Ⅱ ON THE PHOTOSENSITJZATION DAMAGE OF DNA ³¹P NMR INVESTIGATION

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