波谱学杂志 ›› 1992, Vol. 9 ›› Issue (2): 183-188.

• 研究论文 • 上一篇    下一篇

四氢β-咔啉类化合物的13C NMR研究

杨宪斌, 江忝益, 彭师奇, 张黎   

  1. 北京医科大学天然药物及仿生药物国家重点实验室, 北京 100083
  • 收稿日期:1991-05-27 修回日期:1991-07-20 出版日期:1992-06-05 发布日期:2018-01-20

THE STUDY ON 13C NMR OF TETRAHYDRO-β-CARBOLINES

Yang Xianbin, Jiang Tianyi, Peng Shiqi, Zhang Li   

  1. National Laboratory of Natural and Biomimetic Drugs Beijing Medical University, Beijing 100083
  • Received:1991-05-27 Revised:1991-07-20 Online:1992-06-05 Published:2018-01-20

摘要: 测定了四对新合成的四氢β-咔啉化合物的13C NMR谱,通过APT、HETCOR和HETCOLOC谱指认了所有碳的归属.所确定的化学位移规律可以用来确定它们的构型.

关键词: 四氢β-咔啉, 13C NMR, 构型

Abstract: 13C NMR spectra for the four pairs of new tetrahydro-β-carbolines are reported. Chemical shift assignments have been made for all carbons of the tetrahydro-β-carbolincs by APT, HETCOR & HETCOLOC spectra. The chemical shifts of 5-C & 6 -C can be used for configurational assignments of tetrahydro-β-carbolines, for 5-C & 6-C chemical shifts are easily recongnizable. The downfield one is assigned to 5-C & the upfield one assigned to 6-C. In the spectra of 3a, b & 4a, b, both 3-C & 5-C undergo downfield shifts, compared with the corresponding carbons of la, b & 2a, b. Meanwile, 2 -C & 6-C undergo upfield shifts, presumably owing to slight difference in polarization of the C -N bonding electrons.

Key words: Tetrahydro-β-carboline, 13C NMR, Configuration