糖尿病大鼠视神经病变方向性扩散加权MRI表现

波谱学杂志 ›› 2009, Vol. 26 ›› Issue (4): 485-491.

糖尿病大鼠视神经病变方向性扩散加权MRI表现

1.波谱与原子分子物理国家重点实验室, 武汉磁共振中心（中国科学院武汉物理与数学研究所），湖北武汉 430071； 
2.中国科学院研究生院，北京 100049

收稿日期:2009-06-08 修回日期:2009-07-31 出版日期:2009-12-05 发布日期:2009-12-05
基金资助:
国家自然科学基金资助项目(30870674).

Early Pathological Changes in the Optic Nerves of STZ-Treated Diabetic Rats Revealed by Directional Diffusion-Weighted MRI

1.State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Center for Magnetic Resonance(Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences), Wuhan 430071, China; 
2. Graduate School of the Chinese Academy of Sciences, Beijing 100049, China

Received:2009-06-08 Revised:2009-07-31 Online:2009-12-05 Published:2009-12-05
Supported by:
国家自然科学基金资助项目(30870674).

摘要/Abstract

摘要：

利用扩散加权磁共振成像技术研究了链脲佐菌素（STZ）诱导大鼠糖尿病4周时视神经的病理改变. 测量平行和垂直于视神经方向上的水质子的表观扩散系数，分别用ADC_∥和ADC_⊥来表示. 初步结果显示模型组左右侧视神经ADC_∥没有出现一致的改变，而ADC_⊥都有下降的趋势，但没有达到统计显著性. 该结果提示STZ诱导4周后扩散成像测量参数ADC_⊥的改变可能反映了糖尿病引起的视神经轴突损伤.

关键词: 扩散磁共振成像(MRI), 视神经, , STZ, 糖尿病

Abstract:

Type-I diabetes was induced in rats by a single injection of streptozotocin (STZ). Directional diffusion-weighted imaging on the optic nerves were performed one month later to monitor the early optic neuropathy (e.g., axonal injury and myelin sheaths damage) induced by diabetes. Water diffusivities parallel and perpendicular to the axonal tracts were measured by apparent diffusion coefficients ADC_∥ and ADC_⊥, respectively. Compared to the control animals, the STZ-treated animals showed a trend of reduced ADC_⊥ in bilateral optic nerves, but less consistent changes in ADC_∥.

Key words: MRI, diffusion, optic nerves, streptozotocin, diabetes

中图分类号:

R445.2

高丽凤, 黄明明, 雷皓. 糖尿病大鼠视神经病变方向性扩散加权MRI表现[J]. 波谱学杂志, 2009, 26(4): 485-491.

GAO Li-Feng, HUANG Ming-Ming, LEI Hao. Early Pathological Changes in the Optic Nerves of STZ-Treated Diabetic Rats Revealed by Directional Diffusion-Weighted MRI[J]. Chinese Journal of Magnetic Resonance, 2009, 26(4): 485-491.

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