波谱学杂志 ›› 1998, Vol. 15 ›› Issue (5): 441-446.

• 研究论文 • 上一篇    下一篇

噻胺酮麻醉剂对鼠S180肿瘤31P MRS的影响

田建广1, 杜泽涵1, 赵小勇1, 李光玉1, 冯锐1, 魏昌华2, 王静菁2, 茹祥斌2   

  1. 1. 军事医学科学院国家生物医学分析中心, 北京 100850;
    2. 军事医学科学院毒物药物研究所, 北京 100850
  • 收稿日期:1998-04-20 出版日期:1998-10-05 发布日期:2018-01-17
  • 作者简介:田建广,男,27岁,博士生

THE EFFECTS OF ANAESTHETIC AGENT-SAANONE ON 31P MRS IN MURINE S180 TUMORS

Tian Jianguang1, Du Zehan1, Zhao Xiaoyong1, Li Guangyu1, Feng Rui1, Wei Changhua2, Wang Jingjing2, Ru Xiangbin2   

  1. 1. National Center for Biomedial Analysis, Beijing 100850;
    2. Institute of Pharmacology and Toxicology, Academy of Military Sciences, Beijing 100850
  • Received:1998-04-20 Online:1998-10-05 Published:2018-01-17

摘要: 对实验动物肿瘤进行活体31P MRS研究首要的是有效地固定动物.本文初步研究了用噻胺酮麻醉后的小鼠S180肿瘤在麻醉过程中31P MRS随时间的变异性.研究发现噻胺酮是一个安全系数高、起效快、麻醉过程适宜且对肿瘤的31P MRS无显著影响的麻醉药.因而噻胺酮适用于连续测定31P MRS的需要.

关键词: 噻胺酮, 鼠肿瘤, 31P MRS

Abstract: Immobilization of experimental animals is a basic requirement for in vivo 31P MRS measurements.This article studied the time-dependent effects of saanone on 31P MRS in murine S180 tumors.The results showed that saanone is a good anaesthetic agent with high safety index, fast action, moderate anaesthetic time period and no significant side effects on 31P MRS in tumors.So saanone is suitable for serial measurements of 31P MRS.

Key words: Saanone, Murine tumor, 31P MRS