磁共振弹性成像技术在肝纤维化检测中

波谱学杂志

磁共振弹性成像技术在肝纤维化检测中

汪红志^1,2,5*，刘翔¹，王鹤³，陈珊珊^1,5，黄清明^1,5，王晓琰⁴，陆伦⁴，黄勇^1,5，程红岩⁴，李鲠颖 

1. 上海理工大学医学影像工程研究所，上海 200093； 
2. 华东师范大学物理系，上海市磁共振重点实验室，上海200062； 
3. 通用电器医疗系统（中国）有限公司，上海 201203； 
4. 第二军医大学附属东方肝胆医院，上海 200438； 
5. 上海医疗器械高等专科学校，上海 200093

收稿日期:2012-08-30 修回日期:2012-09-26 出版日期:2013-06-05 发布日期:2013-06-05
作者简介:汪红志（1975-），男，湖北黄冈人，博士，副教授，主要从事核磁共振成像及分析技术研究. 电话：021-65502671，E-mail: wanghzhi2000@sina.com.
基金资助:
上海市科研创新基金重点资助项目（10YZ237）.

Detection of Liver Fibrosis Using Magnetic Resonance Elastography

WANG Hong-zhi^1,2,5*, LIU Xiang^1, WANG He³, CHEN Shan-shan^1,5, HUANG Qing-ming^1,5, WANG Xiao-yan⁴, LU Lun⁴, HUANG Yong^1,5, CHENG Hong-yan⁴, LI Geng-ying², ZHANG Xue-long^1,5

1. Graduate of Medical Imaging Technology, University of Shanghai Science and Technology, Shanghai 200093, China;
2. Shanghai Key Laboratory of Magnetic Resonance Technology, Department of Physics, East China Normal University, Shanghai 200062, China； 
3. GE Healthcare (China), Shanghai 201203, China;
4. Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200438, China;
5. Shanghai Medical Instrument College, Shanghai 200093, China

Received:2012-08-30 Revised:2012-09-26 Online:2013-06-05 Published:2013-06-05
About author:Wang Hong-zhi,Tel: 021-65502671，E-mail: wanghzhi2000@sina.com.
Supported by:
上海市科研创新基金重点资助项目（10YZ237）.

摘要/Abstract

摘要：

对肝脏组织的弹性应力分析在肝纤维化程度的精确定量评价方面是非常关键的，因此从弹性力学角度结合磁共振成像技术的磁共振弹性成像研究在肝脏疾病的早期诊断和治疗方面将具有重要意义和广泛应用. 该文针对弹性磁共振成像技术的理论与技术进行了全面的研究，开发了磁共振弹性图研究平台，主要包括：组织生物力学模型分析与建模，剪切波激励装置的开发，弹性成像序列的设计，弹性拟合算法研究与实现4个方面的工作. 基于上述工作，进行了相关体模和离体猪肝以及志愿者在体肝脏实验，实验结果表明，研究平台基本可以满足肝脏弹性成像研究的需要.

关键词: 磁共振弹性成像(MRE), , 肝纤维化, 局域频率估算, 弹性, 肝脏

Abstract:

Magnetic resonance elastography can be used to measure the elastic stress of the liver and the extent of hepatic fibrosis quantitatively. This paper describes the principles and practical implementation of magnetic resonance elastography, including tissue biomechanical model analysis, development of the shear wave developing stimulator, design of elastic imaging sequence and fitting algorithms for elastography. Magnetic resonance elastography measurements on ex vivo pork liver and human volunteers were demonstrated experimentally.

Key words: magnetic resonance elastography, hepatic fibrosis, local frequency estimation, elasticity, liver

中图分类号:

O482.53

汪红志1,2,5*，刘翔1，王鹤3，陈珊珊1,5，黄清明1,5，王晓琰4，陆伦4，黄勇1,5，程红岩4，李鲠颖 . 磁共振弹性成像技术在肝纤维化检测中[J]. 波谱学杂志.

WANG Hong-zhi1,2,5*, LIU Xiang1, WANG He3, CHEN Shan-shan1,5, HUANG Qing-ming1,5, WANG Xiao-yan4, LU Lun4, HUANG Yong1,5, CHENG Hong-yan4, LI Geng-ying2, ZHANG Xue-long1,5. Detection of Liver Fibrosis Using Magnetic Resonance Elastography[J]. Chinese Journal of Magnetic Resonance.

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