波谱学杂志 ›› 2011, Vol. 28 ›› Issue (3): 366-373.

• 研究论文 • 上一篇    下一篇

双黄连口服液1H NMR质量稳定性分析方法研究

沙沂*,李文,李宁,肖皖   

  1. 沈阳药科大学,辽宁 沈阳 110016
  • 修回日期:2010-02-13 出版日期:2011-09-05 发布日期:2011-09-05

Analysis of Quality Stability of Shuanghuanglian Oral Liquid by 1H NMR

 SHA Yi*, LI Wen, LI Ning, XIAO Wan   

  1. Shenyang Pharmaceutical University, Shenyang 110016, China
  • Revised:2010-02-13 Online:2011-09-05 Published:2011-09-05

摘要:

采用NOESYPR1D(水峰抑制)技术,测定双黄连口服液的1H NMR谱图,用Mnova和Excel 2003软件分析处理谱图,以相似度为指标,判别分析不同厂家、不同批次的双黄连口服液中主要成分的差异. 所建立的双黄连口服液的1H NMR质量分析方法可以有效判别不同批次双黄连口服液质量的差异.  实验方法简单、快速、稳定、重现性好,可以为中药成方制剂的质量评价提供新的思路和方法.

关键词: NOESYPR1D(水峰抑制)技术, 双黄连口服液, 质量稳定性

Abstract:

The 1H NMR NOESYPR1D technique was used to analyze quality stability of complex prescription Chinese drugs. Shuanghuanglian oral liquid produced by different companies was analyzed by the method, and indices for similarity were established. The results showed that the method described in the paper can be used to assess the quality of Shuanghuanglian oral liquid effectively.

Key words: NOESYPR1D, Shuanghuanglian oral liquid, quality stability

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