波谱学杂志 ›› 2010, Vol. 27 ›› Issue (3): 386-395.

• MRI方法学 • 上一篇    下一篇

采用超导量子干涉组件在微特斯拉磁场下获取超极化3He的核磁共振波谱和影像

陈名杰1, 廖书贤1, 杨鸿昌1*, 洪姮娥1, 陈信贤2, 杨谢乐2,3   

  1. 1. 台湾大学 物理学暨应用物理研究所, 台湾 台北 106; 2. 台湾师范大学 光电科技研究所, 台湾 台北 116; 3. 磁量生技股份有限公司, 台湾 台北县 231
  • 收稿日期:2010-07-14 出版日期:2010-09-05 发布日期:2010-09-05

Nuclear Magnetic Resonance and Imaging of Hyperpolarized 3He Using High-Tc Superconducting Quantum Interference Device in Microtesla Magnetic Fields

CHEN Ming-Jye1, LIAO Shu-Hsien1, YANG Hong-Chang1, HORNG Herng-Er1, CHEN Hsin-Hsien2, YANG Shieh-Yueh2,3   

  1. 1. Graduate Institute of Applied Physics/Department of Physics, National Taiwan University, Taipei 106;
    2. Institute of Electro optical Science and Technology, National Taiwan Normal University,  Taipei 116;
    3. MagQu Co., Ltd, Sindian City, Taipei County 231
  • Received:2010-07-14 Online:2010-09-05 Published:2010-09-05

摘要:

该文以超导量子干涉元件研究光激发氦三极化气体的低磁场磁共振与造影术. 使用圆偏极化雷色光将氦三气体极化, 超导量子干涉元件磁共振与造影之测量是以磁通耦合方式来进行, 超导量子干涉元件是用铋锶钙铜氧高溫超导罐来隔离环境噪音. 此方法测得的磁共振信号与影像相较于直接将样品置于杜瓦瓶下方有较高的信噪比, 当样品无法靠近感测元件时, 此装置具高信噪比特色. 磁通耦合方式的超导量子干涉元件低磁场磁共振与造影术及其氦三极化气体的肺部造影在学术与应用上是相当有趣.

关键词: 氦三极化气体, 磁共振造影术, 超导量子干涉元件

Abstract:

A study of nuclear magnetic resonance and imaging (NMR/MRI) of optically pumped hyperpolarized 3He using high Tc superconducting quantum interference device (SQUID) in microtesla fields was reported. Hyperpolarized 3He was obtained by pumping optical cell containing 3He, N2, 4He and a few grams of Rb metal using a circularly polarized laser. In the characterization of 3He the precession spins of 3He were coupled to the SQUID magnetometer by a flux transformer. The SQUID and was designed within a superconducting Bi2Sr2Ca2Cu3Oy vessel to avoid environmental noises. The NMR signal using the flux transformer shows an enhancement in signal-to-noise ratio over that directly measured by the SQUID magnetometer. The SQUID-detected NMR/MRI using hyperpolarized 3He can be of interest for lung imaging in ultralow magnetic fields.

Key words: Nuclear Magnetic Resonance, SQUID, optical pumping

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