波谱学杂志 ›› 1993, Vol. 10 ›› Issue (2): 177-184.

• 研究论文 • 上一篇    下一篇

2,4-二氨基-6-(取代苄基)-5-甲基吡啶(2,3d)并嘧啶类化合物的13C NMR研究

封春梅1, 乔梁1, 高从元1, 张怡2, 李仁利2   

  1. 1. 北京医科大学波谱分析室, 北京 100083;
    2. 北京医科大学药化教研室
  • 收稿日期:1992-03-20 修回日期:1992-09-13 出版日期:1993-06-05 发布日期:2018-01-20
  • 基金资助:
    国家自然科学基金

13C NMR STUDY ON 2,4-DIAMINO-5-METHYL-6-SUBSTITUTED-BENZYL PYRIDO-(2,3d) PYRIMIDINES

Feng Chunmei1, Qiao Liang1, Gao Congyuan1, Zhang Yi2, Li Renli2   

  1. Beijing Medical University, Beijing 100083
  • Received:1992-03-20 Revised:1992-09-13 Online:1993-06-05 Published:2018-01-20

摘要: 2,4-二氨基-6-(取代苄基)-5-甲基吡啶(2,3d)并嘧啶类化合物是一类很有前途的抗癌新药。本文研究了24种7位氯代和氧代的该类化合物的碳谱,归属了母核及取代苄基上各碳的化学位移,并对两种取代对母核碳上的化学位移的影响规律进行了探讨,文中所有数据迄今未见文献报道。

关键词: 13C NMR, 2,4-二氨基-6-(取代苄基)-5-甲基吡啶(2,3d)并嘧啶

Abstract: 2,4-diamino-5-methyl-6-substituted-benzyl pyrido-(2,3d) pyrimidines are a kind of promising anticancer drugs. 13C NMR spectra of 24 kinds of 7-chloro and 7-oxo compounds have been studied in this paper. The chemical shifts of all carbons in the parent nuclei and subitituted benzyl have successfully been assigned. The influential factors on chemical shifts of all carbons in parent nuclei for two substituted groups have been approached in depth. To date, the data in this paper have not been published in the world.

Key words: 13C NMR, 2,4-diamino-5-methyl-6-substituted-benzyl pyrido-(2,3d) pyrimidines