LC-DAD-SPE-NMR/MS技术用于卡巴他赛注射液中微量未知杂质的鉴定
Identification and Structural Characterization of an Unknown Trace Degradation Impurity in Cabazitaxel Injection by LC-DAD-SPE-NMR/MS
LC-DAD-SPE-NMR/MS技术用于卡巴他赛注射液中微量未知杂质的鉴定 |
| 刘红兵, 刘惠丽, 罗立廷, 孙丽娟, 陈雷 |
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Identification and Structural Characterization of an Unknown Trace Degradation Impurity in Cabazitaxel Injection by LC-DAD-SPE-NMR/MS |
| LIU Hongbing, LIU Huili, LUO Liting, SUN Lijuan, CHEN Lei |
| 图7 降解杂质(a) 1H-13C HMBC谱局部及(b)关键氢-碳多键相关；卡巴他赛(d) 1H-13C HMBC谱局部及(c)关键氢-碳多键相关 |
| Fig. 7 Part of 1H-13C HMBC spectra and key 1H-13C multiple-bond correlations of degradation impurity [(a), (b)] and cabazitaxel [(d), (c)] |
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