LC-DAD-SPE-NMR/MS技术用于卡巴他赛注射液中微量未知杂质的鉴定

刘红兵, 刘惠丽, 罗立廷, 孙丽娟, 陈雷

Identification and Structural Characterization of an Unknown Trace Degradation Impurity in Cabazitaxel Injection by LC-DAD-SPE-NMR/MS

LIU Hongbing, LIU Huili, LUO Liting, SUN Lijuan, CHEN Lei

图1 卡巴他赛及其新降解杂质化学结构及其降解机制. *降解杂质中除15-17位碳原子外，其余碳原子编号与卡巴他赛相同

Fig. 1 Chemical structures of cabazitaxel and its degradation impurity and the possible formation mechanism. * The number of carbon atoms of the degradation impurity is the same as of cabazitaxel besides C-15, C-16, and C-17