基于核自旋单重态的活体谷胱甘肽分子MRS信号选择
In Vivo Glutathione Molecular MRS Signal Selection Based on Nuclear Spin Singlet States
基于核自旋单重态的活体谷胱甘肽分子MRS信号选择 |
| 朱向炜, 杨雪, 魏达秀, 姚叶锋 |
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In Vivo Glutathione Molecular MRS Signal Selection Based on Nuclear Spin Singlet States |
| ZHU Xiangwei, YANG Xue, WEI Daxiu, YAO Yefeng |
| 图5 基于Siemens 3T-Prisma成像仪平台的人脑活体GSH分子靶向1H-MRS图. (a)所选体素位置结构相示意图，其中白色方框即为所选体素范围；(b)运用PRESS序列采集的1H-MRS谱图，截取2.5 ppm~3.5 ppm范围的谱图；(c)应用GSH-SFOC方法采集的5位不同被试者的1H-MRS谱图，截取2.5 ppm~3.5 ppm范围的谱图，谱图被放大5倍. 其中用方框标记的范围为GSH中Cys-CH2的信号. 所有1H-MRS谱图均充零至32 k个数据点，运用大小为3.8的高斯窗函数进行了处理 |
| Fig. 5 Results of in vivo GSH molecular targeted 1H-MRS in human brain collected on the Siemens 3T-Prisma imaging system. (a) The schematic diagram of the selected voxel position with the white box indicating the selected voxel range. (b) The 1H-MRS spectrum acquired using the PRESS sequence, with a schematic representation of the 2.5~3.5 ppm range. (c) The 1H-MRS spectra collected using the SFOC method, with the spectra magnified by 5 times and the 2.5~3.5 ppm range highlighted in the box indicating the GSH Cys-CH2 signal. All 1H-MRS spectra were zero-filled to 32 k data points and processed using a Gaussian window function with a size of 3.8 |
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