达罗他胺中间体合成中杂质的发现和结构表征
Discovery and Structural Characterization of Impurities in the Synthesis of Darolutamide Intermediate
达罗他胺中间体合成中杂质的发现和结构表征 |
| 马卉芳,童悦,王荣繁,谢建伟 |
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Discovery and Structural Characterization of Impurities in the Synthesis of Darolutamide Intermediate |
| MA Huifang,TONG Yue,WANG Rongfan,XIE Jianwei |
| 图1 达罗他胺（7）的原研合成路线. THF：四氢呋喃；PPh3：三苯基膦；DIAD：偶氮二碳酸二异丙酯；DIPEA：N,N-二异丙基乙胺；HOBt：1-羟基苯并三唑；EDCI：1-乙基-3-(3-二甲基氨基丙基)碳二亚胺盐酸盐 |
| Fig. 1 Original synthesis route of darolutamide (7). THF: tetrahydrofuran; PPh3: triphenylphosphine; DIAD: diisopropyl azodicarboxylate; DIPEA: N,N-diisopropylethylamine; HOBt: 1-hydroxybenzotriazole; EDCI: 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide |
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