海博麦布结构确证

徐肖杰,陈延安,李旭飞,张云才,张勇,詹冬凯,潘婷

Structural Elucidation of Hybutimibe

XU Xiaojie,CHEN Yan’an,LI Xufei,ZHANG Yuncai,ZHANG Yong,ZHAN Dongkai,PAN Ting

表2 海博麦布和依折麦布[8]NMR数据比较（溶剂均为CDCl3）

Table 2 Comparison of NMR data of hybutimibe and ezetimibe[8] in CDCl3

Assignment δC δH hybutimibe ezetimibe hybutimibe ezetimibe 4 26.9(CH2) 24.50(CH2) 2.85(m, 2H) 1.73, 1.83 7 59.6(CH2) / 4.50, 4.58(d, J=12.4 Hz, 2H) 2 59.9(CH) 59.40(CH) 3.25(m, 1H) 3.09 3 60.3(CH) 59.58(CH) 4.73(d, J =2.0 Hz, 1H) 4.81 10,12 115.3(CH, 22) 114.64(CH, 21.0) 6.98(t, J =8.7 Hz, 2H) 7.11 22,24 115.9(CH, 23) 115.79(CH, 22.5) 6.92(t, J=8.6 Hz, 2H) 7.13 16,18 116.2(CH) 115.71(CH) 6.84(d, J=8.4 Hz, 2H) 6.76 21,25 118.7(CH, 8) 118.22(CH, 8.0) 7.26(dd, J=4.6/8.9 Hz, 2H) 7.22 5 126.1(CH) 36.36(CH2) 5.84(t, J=8.1 Hz, 1H) 1.73 15,19 127.4(CH) 127.52(CH) 7.18(d, J=8.4 Hz, 2H) 7.18 9,13 128.1(CH, 8) 127.50(CH, 9.0) 7.38(dd, J=5.5/8.5 Hz, 2H) 7.32 14 128.8(C) 127.88(C) / 20 133.6(C, 2) 133.98(C, 2.3) / 8 137.0(C, 4) 142.19(C, 2.9) / 6 141.2(C) 71.05(CH) / 4.50 17 156.3(C) 157.42(C) / 1.73, 1.83 23 159.2(C, 243) 157.05, 158.96(C, 240.2) / 11 162.3(C, 245) 160.06, 161.98(C, 241.5) / 3.09 1 167.8(C) 167.33(C) / 4.81