新型吡唑并[3,4-d]嘧啶-4-酮类衍生物的结构表征和镇痛活性

翟重钢,汪鹏程,单玉宝,兰昱,胡锐,杨运煌

Structure Characterization and Analgesic Activity of Novel Pyrazolo[3,4-d]pyrimidin-4-one Derivatives

ZHAI Chonggang,WANG Pengcheng,SHAN Yubao,LAN Yu,HU Rui,YANG Yunhuang

图1 (a)根据药效团模型筛选出的化合物结构骨架[6]；(b)化合物A、B和C的合成路线. 化合物3、4、5和6按照文献[9,10]报道的方法制备，化合物7和8参考威廉姆森醚合成反应[11]制备

Fig. 1 (a) The skeleton of the compounds screened by the pharmacophore model[6]; (b) Synthesis of compounds A, B