新型吡唑并[3,4-<i>d</i>]嘧啶-4-酮类衍生物的结构表征和镇痛活性

新型吡唑并[3,4-d]嘧啶-4-酮类衍生物的结构表征和镇痛活性

翟重钢,汪鹏程,单玉宝,兰昱,胡锐,杨运煌

Structure Characterization and Analgesic Activity of Novel Pyrazolo[3,4-d]pyrimidin-4-one Derivatives

ZHAI Chonggang,WANG Pengcheng,SHAN Yubao,LAN Yu,HU Rui,YANG Yunhuang

表3 化合物C的¹H NMR实验数据（溶剂：DMSO-d₆）

Table 3 ¹H NMR experimental data of compound C (solvent: DMSO-d₆)

编号	δ_H	氢原子个数	谱峰裂分(J/Hz)	归属
1	1.95	2	p (6.6)	H-14
2	2.28	3	s	H-16
3	2.31	3	s	H-17
4	2.52	2	t (7.0)	H-15
5	2.55	4	t (6.8)	H-18, H-21
6	2.64	3	s	H-12
7	3.13	4	t (5.5)	H-19, H-20
8	4.29	2	t (6.2)	H-13
9	6.77	1	t (7.3)	H-25
10	6.93	2	d (8.1)	H-23, H-27
11	7.21	2	dd (8.7/7.2)	H-24, H-26
12	7.30	1	d (8.2)	H-2
13	7.71	1	dd (8.2/2.3)	H-1
14	7.75	1	d (2.3)	H-5
15	8.31	1	s	H-9