新型吡唑并[3,4-d]嘧啶-4-酮类衍生物的结构表征和镇痛活性

翟重钢,汪鹏程,单玉宝,兰昱,胡锐,杨运煌

Structure Characterization and Analgesic Activity of Novel Pyrazolo[3,4-d]pyrimidin-4-one Derivatives

ZHAI Chonggang,WANG Pengcheng,SHAN Yubao,LAN Yu,HU Rui,YANG Yunhuang

表2 化合物B的1H NMR实验数据（溶剂：DMSO-d6）

Table 2 1H NMR experimental data of compound B (solvent: DMSO-d6)

编号 δH 氢原子个数 谱峰裂分(J/Hz) 归属 1 1.91 2 p (6.5) H-14 2 2.28 3 s H-16 3 2.31 3 s H-17 4 2.38 4 t (6.8) H-18, H-21 5 2.48 2 t (7.0) H-15 6 2.62 3 s H-12 7 3.58 4 t (4.5) H-19, H-20 8 4.27 2 t (6.3) H-13 9 7.31 1 d (8.1) H-2 10 7.71 1 dd (8.1/2.3) H-1 11 7.75 1 d (2.3) H-5 12 8.31 1 s H-9