新型吡唑并[3,4-d]嘧啶-4-酮类衍生物的结构表征和镇痛活性

翟重钢,汪鹏程,单玉宝,兰昱,胡锐,杨运煌

Structure Characterization and Analgesic Activity of Novel Pyrazolo[3,4-d]pyrimidin-4-one Derivatives

ZHAI Chonggang,WANG Pengcheng,SHAN Yubao,LAN Yu,HU Rui,YANG Yunhuang

表1 化合物A的1H NMR实验数据（溶剂：DMSO-d6）

Table 1 1H NMR experimental data of compound A (solvent: DMSO-d6)

编号 δH 氢原子个数 谱峰裂分(J/Hz) 归属 1 1.39 2 p (5.9) H-20 2 1.49 4 p (5.5) H-19, H-21 3 1.89 2 p (6.6) H-14 4 2.28 3 s H-16 5 2.31 3 s H-17 6 2.33 4 t (6.8) H-18, H-22 7 2.43 2 t (7.0) H-15 8 2.62 3 s H-12 9 4.25 2 t (6.2) H-13 10 7.31 1 d (8.1) H-2 11 7.71 1 dd (8.1/2.3) H-1 12 7.74 1 d (2.3) H-5 13 8.31 1 s H-9