分子影像新技术——氘代谢波谱及成像的综述与展望

张怡,楼飞洋,方可,陈高,张孝通

Review of a New Molecular Imaging Method——Deuterium Metabolic Spectroscopy and Imaging

Yi ZHANG,Fei-yang LOU,Ke FANG,Gao CHEN,Xiao-tong ZHANG

图2 氢/氘双核线圈三维透视图以及肿瘤/对照小鼠的氘代谢波谱结果：射频线圈采用同轴嵌套结构将氢、氘两个鸟笼天线一体化封装，线圈中心为小动物支撑床，同时配以咬合棒、耳棒用以动物保定装置；肿瘤组和对照组小鼠的氘代谢波谱显示（左上），二者皆有重水及氘代葡萄糖谱峰，但仅有肿瘤组可见明显的氘代乳酸谱峰，符合肿瘤细胞代谢特性

Fig.2 The perspective view of 1H/2H RF coil design and DMS results. Two concentric birdcages whose rungs are azimuthally interleaved with each other for better decoupling are housed in a polycarbonate cylinder. The animal holder, bed, bite stick and ear bar are placed in the coil core for animal support, orientation, and anesthesia. DMS result of control mice and tumor mice is illustrated at the top left. Notice that both heavy water and deuterium-labeled glucose signals can be detected, whereas the deuterium-labeled lactate signal can only be identified in tumor group