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T69E模拟磷酸化修饰对Bcl-2与Nur77相互作用的影响
徐倩1,2,陈朗1,2,胡翔颖1,李从刚1,刘乙祥1,*(),姜凌1,*()
The Effect of T69E-mimicked Phosphorylation on the Interaction Between Bcl-2 and Nur77
Qian XU1,2,Lang CHEN1,2,Xiang-ying HU1,Cong-gang LI1,Yi-xiang LIU1,*(),Ling JIANG1,*()

图5. 野生型胞内全长Bcl-2（wtBcl-2）及其T69E突变体与Nur77 LBD结构域（wtNur77）解离常数（KD）的拟合.(a) wtNur77滴定wtBcl-2的15N-1H TROSY谱图和数据拟合；(b) wtNur77滴定T69E突变体的15N-1H TROSY谱图和数据拟合

Fig.5. Data fitting of the dissociation constants between wtBcl-2 or T69E mutant and wtNur77. (a) 15N-1H TROSY spectra and the fitting plots of wtBcl-2 titrated with wtNur77; (b) 15N-1H TROSY spectra and the fitting plots of T69E mutant titrated with wtNur77