T69E模拟磷酸化修饰对Bcl-2与Nur77相互作用的影响
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徐倩 1,2,陈朗 1,2,胡翔颖 1,李从刚 1,刘乙祥 1,*( ),姜凌 1,*( )
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The Effect of T69E-mimicked Phosphorylation on the Interaction Between Bcl-2 and Nur77
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Qian XU 1,2,Lang CHEN 1,2,Xiang-ying HU 1,Cong-gang LI 1,Yi-xiang LIU 1,*( ),Ling JIANG 1,*( )
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图4. T69E突变体的功能验证.(a) 野生型胞内全长Bcl-2(wtBcl-2,蓝色)及其T69E突变体(红色)的15N-1H TROSY谱图比较;(b) Nur77 LBD(wtNur77)滴定T69E突变体的15N-1H TROSY谱图
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Fig.4. Functional validation of T69E mutant. (a) 15N-1H TROSY spectra of wtBcl-2 (blue) and T69E mutant (red); (b) 15N-1H TROSY spectra of T69E mutant titrated with wtNur77
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