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T69E模拟磷酸化修饰对Bcl-2与Nur77相互作用的影响
徐倩1,2,陈朗1,2,胡翔颖1,李从刚1,刘乙祥1,*(),姜凌1,*()
The Effect of T69E-mimicked Phosphorylation on the Interaction Between Bcl-2 and Nur77
Qian XU1,2,Lang CHEN1,2,Xiang-ying HU1,Cong-gang LI1,Yi-xiang LIU1,*(),Ling JIANG1,*()

图3. 野生型胞内全长Bcl-2（wtBcl-2）的活性验证.(a) 15N标记的Nur77 LBD结构域（wtNur77）加入非标记的Bcl-2/xl嵌合体的15N-1H TROSY谱；(b) 15N标记的wtNur77加入非标记的wtBcl-2的15N-1H TROSY谱；(c) 15N标记的wtBcl-2加入非标记wtNur77的15N-1H TROSY谱

Fig.3. Functional validation of wild type full-length Bcl-2 (wtBcl-2). (a) 15N-1H TROSY spectra of unlabeled Bcl-2/xl with 15N-labeled Nur77 LBD (wtNur77); (b) 15N-1H TROSY spectra of unlabeled wtBcl-2 with 15N-labeled wtNur77; (c) 15N-1H TROSY spectra of 15N-labeled wtBcl-2 with unlabeled wtNur77