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T69E模拟磷酸化修饰对Bcl-2与Nur77相互作用的影响
徐倩1,2,陈朗1,2,胡翔颖1,李从刚1,刘乙祥1,*(),姜凌1,*()
The Effect of T69E-mimicked Phosphorylation on the Interaction Between Bcl-2 and Nur77
Qian XU1,2,Lang CHEN1,2,Xiang-ying HU1,Cong-gang LI1,Yi-xiang LIU1,*(),Ling JIANG1,*()

图1. Bcl-2信号转导通路及其结构分区.(a)细胞凋亡的两种途径[8]；(b) Bcl-2的结构分区示意图[8]；(c) Bcl-2/xl嵌合体在溶液中的结构[9]（PDB：1G5O），四个BH结构域的颜色与(b)的颜色相对应，红色为Bcl-xl的loop区；(d) Bcl-2-Nur77凋亡信号通路[12]

Fig.1. The signal transduction pathways and the structure of Bcl-2. (a) The two types of apoptosis[8]; (b) The schematic diagram of Bcl-2 structure[8]; (c) The solution structure of Bcl-2/xl, (PDB: 1G5O)[9]. The colors of the four BH motifs correspond to (b), in which the loop of Bcl-xl is shown in red; (d) The signal transduction pathway of Bcl-2-Nur77[12]