基于动态有机钆纳米颗粒的T1-T2双模态MRI造影剂
张菊敏1,2,陈世桢1,2,*(
),周欣1,2
),周欣1,2
Dual-modal MRI T1-T2 Contrast Agent Based on Dynamic Organic Gadolinium Nanoparticles
Ju-min ZHANG1,2,Shi-zhen CHEN1,2,*(),Xin ZHOU1,2
),Xin ZHOU1,2
图2. 有机钆纳米颗粒的表征. (a)低聚物混合物的MALDI-MS谱图；(b)加入TCEP，未调节pH（0 h）和调节pH后2 h的紫外-可见吸收光谱；(c) 调节pH后2 h的水合粒径图；(d) 调节pH后2 h有机钆纳米颗粒的透射电子显微镜照片
Fig.2. Characterizations of organic gadolinium system. (a) MALDI-MS spectrum of the Gd-oligomer mixtures; (b) UV-Vis absorption spectra of organic gadolinium system with TCEP just as prepared (0 h) and after adjusting pH for 2 h; (c) Hydrodynamic diameters of organic Gd-nanoparticles after adjusting pH for 2 h detected by DLS; (d) TEM image of Gd-nanoparticles after adjusting pH for 2 h
